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huahana

β-thujaplicin(CAS# 499-44-5)

Waiwai Kemika:

ʻĀpana Molekala C10H12O2
Molar Mass 164.2
ʻO ka mānoanoa 1.0041 (manaʻo koʻikoʻi)
Lae hehee 50-52°C(māmā)
Lae Boling 140°C10mm Hg(māmā)
Lae Flash 128.1°C
Ka hoʻoheheʻe Hiki ʻole i ka wai
Puʻupuʻu mahu 8.98E-05mmHg ma 25°C
Ka nana aku ʻAʻole waihoʻoluʻu, prismatic crystals (hoʻopiʻi hou ʻia mai ka ethanol anhydrous)
kala kala Keʻokeʻo
ʻO Merck 14,9390
pKa 7.06±0.30(Wanamua)
Kūlana Waihona Hoʻopaʻa ʻia i loko o kahi maloʻo, lumi wela
Paʻa Paʻa no 1 makahiki mai ka lā i kūʻai ʻia e like me ka mea i hoʻolako ʻia. Hiki ke mālama ʻia nā hopena i DMSO a i ʻole ethanol ma -20° a hiki i 4 mahina.
Pilikino Hōʻalo i ka pilina me nā oxides
Hōʻike Hōʻike 1.5190 (manaʻo)
MDL MFCD00059582
Haʻawina in vitro Ma U87MG a me T98G glioma cell laina, hinokitiol e hōʻike ana i ka emi ʻana o ka maʻi maʻi, me nā helu IC 50 o 316.5 ± 35.5 a me 152.5 ± 25.3 µM, kēlā me kēia. Hoʻopiʻi ʻo Hinokitiol i ka hana ALDH a me ka hiki ke hoʻololi iā ia iho i loko o nā pūnaewele glioma stem, a kāohi i ka oncogenicity in vitro. Hoʻemi pū ʻo Hinokitiol i ka hōʻike Nrf2 i nā pūnaewele glioma stem ma kahi ʻano hilinaʻi. Hoʻopaʻa ʻo Hinokitiol (0-100 μM) i ka ulu ʻana o ka maʻi maʻi maʻi maʻi ma ke ʻano he nui a hilinaʻi i ka manawa. Hoʻemi ʻo Hinokitiol (5, 10 μM) i ka DNMT1 a me ka UHRF1 mRNA a me ka hōʻike protein, a hoʻonui i ka ʻōlelo TET1 ma o ka hoʻonui ʻana i ka pae 5hmC i nā cell HCT-116. Eia kekahi, hoʻemi ka hinokitiol i ke kūlana methylation a hoʻihoʻi i ka hōʻike mRNA o nā genes MGMT, CHST10, a me BTG4.

Huahana Huahana

Huahana Huahana

Nā hōʻailona pōʻino Xn – Poino
Nā Code Risk 22 - Poino ke aleia
Ka wehewehe palekana 36 - E hoʻohana i nā lole pale kūpono.
WGK Kelemānia 3
RTECS GU4200000

 

Hoʻolauna

ʻO Hinokiol, ka mea i kapa ʻia ʻo α-terpene alcohol a i ʻole Thujanol, he mea hoʻohui kūlohelohe maoli no kekahi o nā mea o ka turpentine. He wai waihoʻoluʻu ʻole ʻo Hinoylol me ka ʻono pine ʻala.

 

He ʻokoʻa ka hoʻohana ʻana o Hinokiol. Hoʻohana nui ʻia ia i ka ʻoihana ʻala a me nā mea ʻala e hoʻohui i ka ʻala a me ka ʻala i nā huahana. ʻO ka lua, hoʻohana ʻia ka waiʻona juniper e like me ka fungicide a me ka mālama ʻana, a hoʻohana pinepine ʻia i ka hoʻomākaukau ʻana i nā disinfectants a me nā fungicides.

 

Nui nā ala e hoʻomākaukau ai i ka juniperol. ʻO ka maʻamau, hiki ke unuhi ʻia e ka distillation o nā aila volatile mai nā lau juniper a i ʻole nā ​​​​mea kanu cypress ʻē aʻe, a laila hoʻokaʻawale ʻia a hoʻomaʻemaʻe ʻia e loaʻa ai ka juniperol. Hiki ke hoʻohuihui ʻia ka waiʻona Hinoki e ka hana kemika.

 

ʻIke palekana o juniperol: ʻAʻole ʻona a manaʻo ʻia he palekana. Ma ke ʻano he hui organik, pono e mālama ʻia a mālama pono ʻia. E hōʻalo i ka pili ʻana me ka ʻili a me nā maka, a holoi koke me ka wai inā loaʻa ka pilikia. Pono e mālama ʻia ma kahi maloʻo a maloʻo.


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