2 4-Dichloro-5-methylpyrimidine（CAS# 1780-31-0)
Pilikia a palekana
| Nā hōʻailona pōʻino | C – ʻAiʻino |
| Nā Code Risk | 34 - Ke kumu o ke kuni |
| Ka wehewehe palekana | S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. S36/37/39 – E hoʻohana i nā lole pale kūpono, nā mīkina lima a me ka pale maka/maka. S45 – Inā loaʻa ka pōʻino a i ʻole ka maikaʻi ʻole, e ʻimi koke i ka ʻōlelo aʻo kino (e hōʻike i ka lepili inā hiki.) S27 – Wehe koke i na lole i haumia. |
| UN ID | UN 3261 8/PG 2 |
| WGK Kelemānia | 3 |
| TSCA | ʻAe |
| HS Code | 29335990 |
| Papa Hazard | 8 |
| Hui Pūʻulu | III |
2 4-Dichloro-5-methylpyrimidine（CAS# 1780-31-0) ʻIkepili
| Hoʻohana | 2, 4-dichloro-5-methylpyrimidine hiki ke hoʻohana i ka hoʻomākaukau ʻana o 2-fluoro-5-trifluoromethylpyrimidine. ʻO 2-fluoro-5-trifluoromethylpyrimidine ka mea koʻikoʻi no ka synthesis o nā lāʻau lapaʻau, hiki ke hoʻohana ʻia e synthesize i nā pūhui dihydrofuran apo fused, a hiki ke hoʻohana ʻia nā pūhui dihydrofuran fused e like me G protein i hui pū ʻia me nā modulators GPR119, no ka mālama ʻana i ka maʻi diabetes, ka momona a me ka maʻi dyslipidemia. Eia kekahi, hiki ke hoʻohana ʻia ka 2-fluoro-5-trifluoromethylpyrimidine ma ke ʻano he waena i ka synthesis o nā lāʻau lapaʻau no ka mālama ʻana i ka maʻi o Alzheimer a me ka schizophrenia. |
| hoomakaukau ana | 5-methyluracil 75g (0.59mol), phosphorus oxychloride 236g, triethylamine hydrochloride 16.5g (0.12mol), i hoʻohui ʻia i ka pahu hopena, i hoʻomehana ʻia i 100 ℃ ~ 110 ℃, Reflux reaction 5H, hoʻoluʻu i 40 ℃, hoʻohui i ka phosphorus 40 ℃ 1.19mol), ka hopena mālama wela 2H. Ma hope o ka pau ʻana o ka hopena, ua hoʻihoʻi ʻia ka phosphorus oxychloride e ka distillation ma lalo o ke kaomi hoʻohaʻahaʻa, a ua hoʻomau ʻia ka distillation ma lalo o ke kaomi hoʻemi ʻia e loaʻa ai ka 88g(0.54mol) o 2, 4-dichloro-5-methylpyrimidine i ka hua o 91.5%. |
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