2 4-Difluorobenzoic acid（CAS# 1583-58-0)

Palapala noi

ʻO 2, 4-difluorobenzoic acid he lāʻau koʻikoʻi a me ka pesticide intermediate, e like me 2, 4-difluorobenzoic acid i hoʻohana nui ʻia e synthesize antifungal lāʻau fluconazole, voriconazole a me ka lāʻau pesticide intermediate 4-fluorosalicylic acid, lāʻau waena 3, 5-difluoroaniline, etc. .A, 2, 4-dicluoroberenzoic e hiki ke hoʻohanaʻia i ka crystal wai nā mea waiwai, nona nā pōmaikaʻi o ka waiwai kiʻekiʻe a me nā kūlana mākeke maikaʻi.

Hoʻomākaukau

E hoʻohui i ka 2, 4-dinitrotoluene a me ka wai i ka ipu pane, hoʻoponopono i ka waiwai pH i 7, hoʻoulu a wela i 75 ° C. Ua hoʻohui ʻia ka potassium permanganate, ka magnesium sulfate a me ka hoʻololi ʻana i ka manawa i nā pūʻulu. Ma hope o ka hoʻohui ʻana, e hoʻomau i ka hoʻoulu ʻana a me ka hana ʻana i ka mahana mau no 3 mau hola. E kānana i ka wā wela a holoi i ka keke kānana me ka wai wela. Hoʻohui i ka filtrate, acidify me 35% hydrochloric acid i ka pH 2-3, aia ka nui o nā keʻokeʻo keʻokeʻo ma hope o ka hoʻopiha piha ʻana o nā kristal, kānana, holoi ʻia, recrystallized, a maloʻo e loaʻa nā kristal keʻokeʻo e like me 2,4-dinitrobenzoic acid. . ʻO ka ratio o 2, 4-dinitrotoluene i ka potassium permanganate he 2.4: 1. ʻO 90.7% ka hua o kēia hana.

e hoʻohui i ka N, N-dimethylmethylphthalamide i loko o ka pahu hopena, wela i 100 ~ 110 ℃, preheat no 0.5 ~ 1h. Hoʻohui i ka anhydrous potassium fluoride maloʻo ma lalo o ka hoʻoulu ʻana a mālama i ka mahana preheated no 0.5-1h. Ma hope o kēlā, ua hoʻohui koke ʻia ka 2, 4-dinitrobenzoic acid a me ka hexyltrimethylammonium bromide i ka moku pane i ka manawa hoʻokahi, a hoʻomau ʻia ka hoʻomehana ʻana i 120 ℃, mālama ʻia ka mahana a hoʻomau ʻia ka hoʻoulu ʻana. Ma hope o 7h o ka reflux reaction, e hoʻihoʻi ʻia ka solvent ma ka distillation, a laila hoʻoheheʻe ʻia ka wai hopena me ka mahu. ʻO ka hakina i hōʻiliʻili ʻia he emulsion keʻokeʻo. Ma hope o ke kū ʻana no kekahi manawa, e hoʻoheheʻe ʻia ka hakina ʻaila i lalo, ninini ʻia ka wai keʻokeʻo keʻokeʻo ma luna, a maloʻo ka ʻaila e hoʻoheheʻe i nā kristal keʻokeʻo e loaʻa ai kahi huahana maʻemaʻe; ʻO ka huahana crude ua recrystallized, Suction kānana, holoi, a maloʻo e loaʻa ke keʻokeʻo kristal o 2,4-difluorobenzoic waikawa. ʻO ka lakio o ka nui o 2, 4-dinitrobenzoic acid i ka potassium fluoride he 2.7:1. ʻO 72.4% ka hua o kēia hana.

Hoʻolauna
ʻO ka 2,4-Difluorobenzoic acid kahi mea hoʻohui. ʻO kēia ka hoʻolauna ʻana i nā waiwai, hoʻohana, nā ʻano hoʻomākaukau a me ka ʻike palekana o ka 2,4-difluorobenzoic acid:

ʻAno maikaʻi:
- Keʻano: 2,4-Difluorobenzoic acid he paʻa keʻokeʻo keʻokeʻo.
- Solubility: Hiki ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe kūlohelohe maʻamau e like me ka ethanol, methanol a me ka methylene chloride.

E hoʻohana:
- Nā meaʻenehana Optical: Hiki ke hoʻohanaʻia e like me kekahi o nā mea maka no ka hoʻomākaukauʻana i nā mea optical a me nā kiʻiʻoniʻoni.
- Nā noi hana: 2,4-difluorobenzoic acid hiki ke hoʻohana ʻia i ka ʻoihana uila, nā uhi a me nā ʻoihana plastics me ka anti-corrosion, anti-oxidation a me nā hopena anti-ultraviolet.

Hanana:
- Hiki ke loaʻa ka 2,4-Difluorobenzoic acid ma ka fluorination o ka waika hydrofluoric me ka p-methylanisole.

ʻIke palekana:
- I ka hana ʻana, pono e pale ʻia ka lepo e pale aku i ka inhalation a me ka pili maka. I ka manawa like, pono e mālama ʻia nā kūlana ventilation maikaʻi.
- Hōʻalo i ka hoʻopili ʻana me nā mea oxidizing ikaika a i ʻole nā ​​​​ʻakika ikaika e pale aku i nā hopena pōʻino