2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine(CAS#865363-93-5)

Ke hoʻolauna nei i ka 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), he mea hoʻohālikelike nucleoside i hoʻonohonoho ʻia e hoʻololi i ke kahua o ka biology molecular a me ka noiʻi lāʻau lapaʻau. Hoʻolālā ʻia kēia pūhui hou e hoʻonui i ka ʻike o ka pilina o ka nucleic acid a me nā kaʻina kelepona, e lilo ia i mea waiwai nui no nā mea noiʻi a me nā ʻepekema like.

ʻO ka 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine ka mea i hōʻikeʻia e kona mau hoʻololi hoʻololi kūikawā,ʻo ia hoʻi ka ethynyl a me ka fluorine pani ma nā kūlana 4' a me 2'. ʻAʻole wale kēia mau hoʻololi e hoʻomaikaʻi i ka paʻa a me ka bioavailability o ka pūhui akā hoʻonui pū i kona hiki ke komo i nā membrane cellular, e ʻae ai i ka lawe ʻana a me ka lawe ʻana i nā ʻōnaehana olaola like ʻole.

Ua hōʻike kēia analog nucleoside i ka hiki ke hoʻohiki i nā noi like ʻole, me ka noiʻi antiviral a me anticancer. ʻO kona hiki ke hoʻohālikelike i nā nucleosides kūlohelohe ʻoiai e hōʻike ana i nā waiwai biochemical kūʻokoʻa e lilo ia i moho kūpono no ka hoʻomohala ʻana i nā mea lapaʻau hou. Hiki i nā mea noiʻi ke hoʻohana i ka 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine e aʻo ai i ka RNA a me DNA synthesis, e noiʻi i nā pilina enzyme, a e ʻimi i nā hana o ka hana o nā lāʻau lapaʻau.

Ma waho aʻe o kāna mau noiʻi noiʻi, ua mākaukau kēia pūhui e pāʻani i kahi hana koʻikoʻi i ka hoʻomohala ʻana i nā lāʻau lapaʻau e hiki mai ana. Ma ka hāʻawi ʻana i nā ʻike i ka hana nucleic acid a me ka launa pū ʻana, hiki i ka 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine ke kōkua i ka hoʻolālā ʻana i nā lāʻau lapaʻau ʻoi aku ka maikaʻi no nā maʻi like ʻole.

I ka hōʻuluʻulu manaʻo, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) he analog nucleoside ʻokiʻoki e hāʻawi ana i nā manawa kūpono ʻole no ka noiʻi a me ka hoʻomohala ʻana i ka biology molecular a me ka lāʻau lapaʻau. Hoʻopili i ka wā e hiki mai ana o ka ʻike ʻepekema me kēia pūhui kūʻokoʻa a wehe i nā mea hou i kāu mau noiʻi noiʻi.