4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile(CAS# 189956-45-4)
4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile(CAS#189956-45-4) ʻIkepili
LogP | 0.9 ma ka pH6.6 |
hoʻohana | 4- [(4-hydroxy-2-pyrimidinyl) amino] benzonitrile hiki ke hoʻohana ʻia ma ke ʻano he waena i ka synthesis organik a me ka intermediate pharmaceutical, a hiki ke hoʻohana ʻia i loko o ke kaʻina hana hoʻomohala Organic a me ka noiʻi a me ka hoʻomohala lāʻau. |
hoomakaukau ana | kaupaona 2-(methylthio) pyrimidine -4(3H)-hoʻokahi (3g,21mmol) a me 4-aminobenzonitrile (2.99g,25mmol) i loko o ka ipu 50mL poʻe lalo, pale ʻia e ka nitrogen, hoʻomehana mālie ʻia i 180 ℃, a hana ʻia no 8 hola. Ma hope o ka maʻalili ʻana o ka hopena, hoʻohui ʻia ka 20mL o ka acetonitrile no ka mālama ultrasonic, kānana, holoi ʻia ka keke kānana me ka acetonitrile, ʻaʻohe 4-aminobenzonitrile koena i ʻike ʻia e TLC, a ʻo ka paʻa melemele māmā i loaʻa ma ka hoʻomaloʻo ʻana i ka keke kānana he 4-( (4-oxo -1, 6-dihydropyrimidine -2-yl) amino) benzonitrile me ka hua o 73.6%. |
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