4-Bromo-3-fluorobenzoic acid (CAS # 153556-42-4)
Hōʻike ʻike
| Hoʻohana | ʻO ka 4-bromo-3-fluorobenzoic acid he mea kemika koʻikoʻi i hiki ke hoʻohana ʻia no ka hoʻomākaukau ʻana i nā lāʻau lapaʻau like ʻole (e like me ka benzamit anti-cancer drug). |
| ʻO ke ʻano hana synthesis | Hiki ke loaʻa ka 4-bromo-3-fluorobenzoic acid ma o ka oxidation o 4-bromo-3-fluorotoluene ma o ka potassium permanganate. (1) oxidation: 100kg o kg4-bromo -3-fluorotoluene, 120kg wai a me 0.1kg o ka momona momona polyether sodium sulfate (AES) i hoʻohui pū ʻia i ka K-400L glass-lineed reaction kettle (i hana ʻia e Jiangsu industrial lining chemical. lako co., ltd.) me ka hoʻoulu ʻana a me ka hoʻomehana a me ka condensation reflux device, a laila Hoʻohui mālie ʻia ka 167kg o ka potassium permanganate ma lalo o ke ʻano hoʻouluulu, mālama ʻia i loko o ke ʻano paila, a hana ʻia no 9 mau hola, hoʻōki i ka hopena ma hope o ka hopena reflux ʻaʻohe mau ʻaila ʻaila; (2) kānana: kānana i ka hopena hopena i loaʻa ma ka ʻanuʻu (1) i ka wā wela e loaʻa ai ka filtrate i loaʻa i ka huahana pahuhopu 4-bromo -3-fluorobenzoic acid; (3) Wehe i ka potassium permanganate: No ka wehe ʻana i ke koena potassium permanganate i loko o ka filtrate, pono e hoʻohui ʻia 0.1kg o ka sodium sulfite i ka kānana i loaʻa ma ka ʻanuʻu (2), ʻo ka hoʻohui ʻana o ka sodium sulfite e hoʻokumu ʻia ma luna o ka wai aniani me ka. ke kala poni o ka hoʻonā. (4) acidification: i ka hoʻoulu ʻana, e hoʻohui mālie i ka mea i ka hopena i loaʻa ma ka ʻanuʻu (3) me kahi ʻano o 12mol/L concentrated hydrochloric acid. inā he 2.2 ka pH o ka hopena, e ho'ōki i ka hoʻohui ʻana i ka waika hydrochloric concentrated a hoʻomau i ka hopena no 30min. (5) crystallization: i ka hoʻoulu ʻana, ʻo ka hopena i loaʻa ma ka ʻanuʻu (4) ua maʻalili i 2 ° C, a ʻo nā kristal i hoʻoheheʻe ʻia i loko o ka hopena he 4-bromo-3-fluorobenzoic acid. I ka wā o ka hana, pono e hoʻoulu mau ʻia, inā ʻaʻole e hana ʻia ka 4-bromo-3-fluorobenzoic acid i kahi paʻa nui, he paʻakikī ke hana i nā kaʻina hana ma hope; (6) Hoʻomaʻemaʻe a me ka holoi ʻana: ʻO ka wai i hui ʻia i loko o ka 4-bromo-3-fluorobenzoic acid crystals i loaʻa i ka ʻanuʻu (5) ua centrifuged no ka loaʻa ʻana o kahi keke kānana ʻo ia ka huahana 4-bromo-3-fluorobenzoic acid, ka huahana pala. holoi ʻia me ka wai maʻemaʻe a me ka centrifuged (hoʻohana i ka centrifuge me ka hana holoi) no ka loaʻa ʻana o ka 4-bromo-3-fluorobenzoic acid; (7) Hoʻomaloʻo: Hoʻomaloʻo ʻia ka 4-bromo-3-fluorobenzoic acid solid i hoʻomākaukau ʻia ma ka pae (6) ma 75 ° C no 12 mau hola e loaʻa ai ka 197 kg4-bromo-3-fluorobenzoic acid, ʻoi aku ka nui ma mua o 98. %. |
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