5-Bromo-3-nitro-2-pyridinol（CAS# 15862-34-7)
Pilikia a palekana
| Nā Code Risk | R22 – Poino ke aleia R37/38 – Hoʻonanea i ka ʻōnaehana hanu a me ka ʻili. R41 – Ka pilikia o ka poino nui i na maka R36/37/38 – Hoʻonanea i ka maka, ka ʻōpū hanu a me ka ʻili. R20 – Poino ma ka inhalation |
| Ka wehewehe palekana | S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. S36/37/39 – E hoʻohana i nā lole pale kūpono, nā mīkina lima a me ka pale maka/maka. S36 – E komo i nā lole pale kūpono. |
| UN ID | 2811 |
| WGK Kelemānia | 3 |
| HS Code | 29337900 |
| Nānā Hazard | ʻinoʻino |
| Papa Hazard | HOOLAHA |
Hōʻike ʻike
| Hoʻohana | ʻO ka 5-bromo-2-hydroxy-3-nitropyridine he mea koʻikoʻi waena i hiki ke hoʻohana ʻia e hoʻomākaukau i nā pūhui 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)-[1,1'-biphenyl ]-4-yl) ethyl)-5-(pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H)-one, ʻo kēia pūhui he mea hoʻopuʻi DOCK1. |
| ʻano hana synthesis | nitric acid (60-61%,3.5mL) i hookomoia i ka solution (10mL) o 5-bromopyridine -2(1H)-one (1.75g,10.1mmol) i ka sulfuric acid ma 0 ℃. ʻAe ʻia ka hui ʻana e hoʻomehana ʻia i ka lumi wela a hoʻoulu ʻia no 3 mau hola. Ua ninini ʻia ka hui ʻana i loko o ka wai hau a ʻohi ʻia ka precipitate i hopena e ka kānana. Ua holoi ʻia ka huahana me ka wai a hoʻomaloʻo ʻia i loko o ka momi, e hāʻawi ana i ka 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% hua) ma ke ʻano he paʻa keʻokeʻo. 1H NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
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