5-Fluorocytosine（CAS# 2022-85-7)
Pilikia a palekana
| Nā Code Risk | R40 - Nā hōʻike liʻiliʻi o ka hopena carcinogenic R36/37/38 – Hoʻonanea i ka maka, ka ʻōpū hanu a me ka ʻili. R63 – Hiki ke pilikia i ke keiki hānau ʻole |
| Ka wehewehe palekana | S22 – Mai hanu i ka lepo. S24/25 – Hōʻalo i ka pili ʻana me ka ʻili a me nā maka. S45 – Inā loaʻa ka pōʻino a i ʻole ka maikaʻi ʻole, e ʻimi koke i ka ʻōlelo aʻo kino (e hōʻike i ka lepili inā hiki.) S36/37 – E hoʻohana i nā lole pale kūpono a me nā mīkina lima. S36/37/39 – E hoʻohana i nā lole pale kūpono, nā mīkina lima a me ka pale maka/maka. S27 – Wehe koke i na lole i haumia. S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. |
| WGK Kelemānia | 2 |
| RTECS | HA6040000 |
| NUI FLUKA BRAND F | 10-23 |
| HS Code | 29335990 |
| Nānā Hazard | ʻona/māmā |
| Papa Hazard | HOOLAHA, NA SENS MALAMA |
| Kaʻawaʻawa | LD50 i nāʻiole (mg/kg): >2000 waha a sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine（CAS# 2022-85-7) Ho‘olauna
maikaʻi
ʻO kēia huahana he pauka keʻokeʻo keʻokeʻo keʻokeʻo keʻokeʻo, ʻaʻala ʻole a ʻala iki paha. Hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia o 1.2% ma 20 °C i ka wai, hiki ke hoʻoheheʻe iki i ka ethanol; Aneane hiki ole ke hooheheeia i ka chloroform a me ka etera; Hiki ke hoʻoheheʻe ʻia i loko o ka dilute hydrochloric acid a i ʻole dilute sodium hydroxide solution. Paʻa ia ma ka lumi wela, hoʻoheheʻe i nā kristal i ke anuanu, a hoʻololi ʻia kahi hapa liʻiliʻi i 5-fluorouracil i ka wā i wela ai.
ʻO kēia huahana he lāʻau antifungal i hoʻohui ʻia i ka makahiki 1957 a hoʻohana ʻia i ka hana lapaʻau ma 1969, me ka hopena antibacterial maopopo ma Candida, cryptococcus, kala kala a me Aspergillus, a ʻaʻohe hopena pale i nā haʻi ʻē aʻe.
ʻO kona hopena paʻa i nā fungi ma muli o kona komo ʻana i loko o nā pūnaewele o nā haʻuki koʻikoʻi, kahi ma lalo o ka hana o ka nucleopyine deaminase, e hoʻoneʻe i nā hui amino e hana i ka antimetabolite-5-fluorouracil. Hoʻololi ʻia ka mea hope i 5-fluorouracil deoxynucleoside a kāohi i koumine nucleoside synthetase, poloka i ka hoʻololi ʻana o ka uracil deoxynucleoside i thymine nucleoside, a pili i ka synthesis DNA.
hoʻohana
Nā lāʻau antifungal. Hoʻohana nui ia no ka mucocutaneous candidiasis, candidal endocarditis, candidal arthritis, cryptococcal meningitis a me chromomycosis.
Ka hoʻohana ʻana a me ka dosage Oral, 4 ~ 6g i ka lā, māhele ʻia i 4 mau manawa.
palekana
Pono e nānā mau ʻia nā helu koko i ka wā o ka lawelawe ʻana. ʻO ka poʻe maʻi me ka lawaʻole o ka ate a me nā puʻupaʻa a me nā maʻi koko a me nā wahine hāpai e hoʻohana me ka akahele; Contraindicated i nā mea maʻi me ka lawa ʻole o ka renal.
Ka malu, ka mālama ʻana i ka ea.
