ALPHA-ISO-METHYLIONONE(CAS#127-51-5)
| Nā hōʻailona pōʻino | Xi – Hoʻohaunaele |
| Nā Code Risk | 43 - Hiki ke hoʻoulu i ka ʻike ma ka pili ʻana i ka ʻili |
| Ka wehewehe palekana | S24/25 – Hōʻalo i ka pili ʻana me ka ʻili a me nā maka. S36/37 – E hoʻohana i nā lole pale kūpono a me nā mīkina lima. |
| UN ID | UN1230 – papa 3 – PG 2 – Methanol, solution |
| WGK Kelemānia | 2 |
| Kaʻawaʻawa | GRAS(FEMA). |
Hoʻolauna
hoolauna
He hui o methyl a me ethyl isomethyl violet ketone a me methyl a me ethyl ortho methyl violet ketone.
ʻano ʻano
ʻO ka alpha isomethylprednisolone kahi pūhui kino. He paʻa aniani poni. Ma ka lumi wela, he ʻala ʻala ʻokoʻa kona.
ʻO ka alpha isomethylprednisolone kahi ketone aromatic. Loaʻa ia mai ka hopena methylation o ka waiʻona violet a ua kapa ʻia ʻo isomethyl violet ketone. Aia i loko o kona ʻano molekala kekahi apo ʻala a me kahi hui ketone.
Ma ka lumi wela, he paʻa, akā hiki ke hoʻoheheʻe ʻia e ka hoʻomehana. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai, akā hiki ke hoʻoheheʻe ʻia i loko o kekahi mau mea hoʻoheheʻe kūlohelohe e like me ka ethanol a me ka dichloromethane. He mea maʻalahi ia i ka mālamalama a hiki ke hana i ka hopena photolysis ma lalo o ka irradiation kukui ultraviolet.
Ma ke ʻano o nā waiwai kemika, ʻo ka α - isomethylprednisolone kahi pūhui reactive. Hiki iā ia ke hana i nā hopena e like me ka oxidation, hōʻemi, hoʻohui, a me ka hoʻololi. Hoʻopili ia me kekahi mau mea electrophilic reagents e hana i nā huahana hoʻohui. Hiki ke protonated ma ke alo o nā ʻakika ikaika. Hiki ke hoʻololi ʻia i loko o nā waikawa ketone ma o nā hopena oxidation.
Hana hana
Eia kekahi ala maʻamau no ka hana ʻana i ka alpha isomethylprednisolone:
Hoʻomākaukau mua: E hoʻomākaukau i nā mea mua, me ka Isobutyl ketone a me Cyclohexanone. ʻO kēia mau pūhui ʻelua he mau precursors nui no ka synthesis o α - isomethylprednisolone.
Ka hoʻonohonoho ʻana i ke kūlana pane: Reacte isodecanone a me cyclohexanol ma lalo o nā kūlana kūpono. ʻO ke ʻano hoʻololi maʻamau ka hana ʻana i ka hopena ma lalo o nā kūlana ʻakika, a ʻo nā mea hoʻoheheʻe waika i hoʻohana maʻamau ʻia me ka waikawa sulfuric (H2SO4) a me ka waikawa phosphoric (H3PO4).
Nā ʻanuʻu pane: Hoʻohui i kahi nui o isodecanone a me cyclohexanol, a hoʻohui i kahi mea hoʻoheheʻe waika. A laila, hoʻokō ʻia ka hopena ma kahi mahana kūpono, me kahi pae wela maʻamau o 50-70 degere Celsius. ʻO ka manawa pane ma ke ʻano he mau hola a i ʻumi mau hola.
Hoʻokaʻawale a hoʻomaʻemaʻe: Ma hope o ka pau ʻana o ka hopena, hoʻomaʻemaʻe ʻia ka huahana mai ka hui ʻana o ka hopena e ka distillation a i ʻole nā ʻano hoʻokaʻawale ʻē aʻe.
Crystallization a maloʻo: Crystallize a hoʻomaloʻo i ka huahana i hoʻomaʻemaʻe ʻia no ka loaʻa ʻana o ka huahana alpha isomethylprednisolone hope loa.
