Boc-Asp-OtBu（CAS# 34582-32-6)
| WGK Kelemānia | 3 |
| HS Code | 2924 19 00 |
Hoʻolauna
ʻO Boc-Asp-OtBu, i ʻike nui ʻia ʻo Boc-Asp-OtBu, he mea hoʻohuihui kino. ʻO kēia ka hoʻolauna ʻana i kekahi o kāna mau waiwai, hoʻohana, hana a me ka ʻike palekana.
ʻAno:
-Nani: ʻO nā mea kristal kala ʻole a i ʻole nā mea pauka.
-Poloke mole: C≡H≡NO-7.
-Molecular kaumaha: 393.47g/mol.
-Ka helu heheʻe: ma kahi o 68-70°C.
-Solubility: Hiki ke hoʻoheheʻe ʻia i loko o kekahi mau mea hoʻoheheʻe kūlohelohe, e like me ka dimethylformamide (DMF) a me ka dichloromethane (DCM).
E hoʻohana:
- ʻO Boc-Asp-OtBu kahi hui pale maʻamau, hoʻohana pinepine ʻia i ka synthesis o nā peptides a me nā pūhui protein. Hiki iā ia ke pale i ka carboxyl a me nā pūʻulu amino o ka glutamic acid (Asp) a pale i nā hopena a me ka hoʻohaʻahaʻa.
- Hiki ke hoʻohana ʻia ʻo Boc-Asp-OtBu ma ke ʻano he mea hoʻohālikelike i ka synthesis organik, e like me ka peptide synthesis a me ka synthesis lāʻau.
Kaʻina hoʻomākaukau:
-Ma ka maʻamau, hoʻomākaukau ʻia ʻo Boc-Asp-OtBu ma ka hana ʻana i ka waikawa amino e pili ana (L-glutamic acid) me kahi hui pale tert-butyl (Boc) a me kahi pūʻulu pale tert-butoxycarbonyl (OtBu). Hoʻokō ʻia ka hopena ma lalo o nā kūlana kūpono, no ka laʻana ma ka hoʻohui ʻana i kahi mea hoʻoulu e like me 1-(trimethylsilyl) -1H-pyrazol-3-one (TBTU) a i ʻole N,N'-diisopropylmethylamide (DIPCDI) i loko o kahi mea hoʻoheheʻe organik.
ʻIke palekana:
- Boc-Asp-OtBu me ka haʻahaʻa haʻahaʻa.
-No ka mea he mea hoʻohuihui ia, e pale aku i ka hanu ʻana i ka lepo a i ʻole ka pili ʻana me ka ʻili a me nā maka.
-I ka wā e hana ai, pono ʻoe e hahai i nā ʻano hana palekana o ka lab, e like me ke komo ʻana i nā mīkina lima pale a me ka pale maka.
-I ka mālama ʻana, pono e mālama ʻia ma kahi maloʻo a maloʻo, a ma kahi mamao aku i ke ahi a me nā mea oxidizing.
ʻO ka ʻike ma luna nei no ka ʻike wale nō, e ʻoluʻolu e hahai i nā kikoʻī hana hoʻokolohua kemika pololei i ka wā e hoʻohana ai a mālama i ka Boc-Asp-OtBu.
