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huahana

BOC-D-ASP(OBZL)-OH(CAS# 92828-64-3)

Waiwai Kemika:

ʻĀpana Molekala C16H21NO6
Molar Mass 323.34
ʻO ka mānoanoa 1.219
Lae Boling 504.3±50.0 °C(Wānana ʻia)
Lae Flash 258.793°C
Puʻupuʻu mahu 0mmHg ma 25°C
Ka nana aku Pauda
kala kala Keʻokeʻo
pKa 4.09±0.19(Wanamua)
Kūlana Waihona Hoʻopaʻa ʻia i kahi maloʻo, 2-8 ° C
Hōʻike Hōʻike 1.527

Huahana Huahana

Huahana Huahana

WGK Kelemānia 3

 

Hoʻolauna

(3R)-4-(benzyloxy)-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (inoa makemake ʻole)((3R)-4-(benzyloxy)-3-[(tert-butoxycarbonyl) amino]-4-oxobutanoic acid) he mea hoʻohuihui mea hoʻoheheʻe ʻia ʻo C16H21NO6.

 

ʻO ka pūhui he derivative o ka aspartic acid me kēia mau waiwai:

-ʻO ka hiʻohiʻona he pauka crystalline keʻokeʻo;

-Stable ma ka lumi wela, akā e decompose ma kiʻekiʻe wela;

-Soluble i loko o nā mea hoʻoheheʻe kūlohelohe maʻamau e like me ka methanol, ethanol a me dichloromethane.

 

(3R)-4-(benzyloxy)-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (inoa i makemake ʻole ʻia) he nui nā mea hoʻohana i ka lāʻau lapaʻau.

-Hoʻohana ʻia ia ma ke ʻano he waena no ka synthesis o polypeptides a me nā pūhui me nā koena aspartic acid i nā protein;

- Hiki ke hoʻohana ʻia ma ke ʻano he synthetic intermediate no nā lāʻau lapaʻau.

 

I loko o ka hale hana, ʻo ke ʻano o ka hoʻomākaukau ʻana (3R) -4-(benzyloxy)-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (inoa makemake ʻole) ʻo ia ka mea maʻamau ma ka hana ʻana i ka hui carboxyl o ka waikawa aspartic me tert-butoxycarbonyl isocyanate, a me ka hoʻokomo ʻana i nā pūʻulu benzyl ester ma o nā hopena hana kūpono.

 

E pili ana i ka ʻike palekana, (3R)-4-(benzyloxy)-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (inoa makemake ʻole ʻia) ua kaupalena ʻia ka ʻona a me ka ʻikepili pōʻino, no laila pono kāna hana palekana e hahai i ka hale hana maʻamau. alakaʻi palekana. E hoʻohana i nā lako pale pilikino kūpono e like me nā makaaniani, nā mīkina lima a me nā ʻaʻahu hale hana i ka wā e hoʻohana ai a lawelawe ʻia paha. I ka manawa like, e pale aku i kona pilina me nā oxidants ikaika a me nā combustibles.


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