BOC-GLY-GLY-GLY-OH（CAS# 28320-73-2)

Hoʻolauna

ʻO Tert-Butoxycarbonylglycyl glycylglycine (Boc-Gly-Gly-Gly-OH) he pūhui mea ola me nā waiwai penei:

ʻAno:

-Ke ʻano: maʻamau keʻokeʻo keʻokeʻo a i ʻole ka pauka crystalline

-Ke kumu molekala: C17H30N4O7

-Molecular kaumaha: 402.44g/mol

-Ka helu heheʻe: ma kahi o 130-132 ° C

-Solubility: Hiki ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe organik e like me dimethylformamide (DMF), dichloromethane, chloroform, etc., hiki ʻole ke hoʻoheheʻe ʻia i ka wai.

E hoʻohana:

Hoʻohana maʻamau ʻia ʻo Boc-Gly-Gly-Gly-OH i ka synthesis organik, ma ke ʻano he pale a i ʻole nā ​​hui. Hiki ke hoʻohana ʻia ma ke ʻano he pūʻulu pale o nā waikawa amino e pale ai i nā hopena kikoʻī ʻole, a hoʻohana maʻamau ʻia i ka synthesis paʻa paʻa, peptide synthesis a me ka synthesis lāʻau.

Hanana:

ʻO ke ala maʻamau no ka hoʻomākaukau ʻana iā Boc-Gly-Gly-Gly-OH ʻo ia ka hoʻokomo ʻana i kahi pūʻulu pale tert-butoxycarbonyl ma ka hui carboxyl o glycine. Loaʻa nā ʻanuʻu kikoʻī:

1. Hoʻopili ʻia ʻo Glycine me ka hui ʻana o ka sodium nitrite a me ka sulfuric acid e loaʻa ai ka tert-butoxycarbonyl glycinate.

2. Hoʻoneʻe ʻia ka hui pale Ester e ka hopena hydrolysis e loaʻa ai ka Boc-glycine.

3. E hana hou i na hana i luna i elua manawa no ka hookomo ana i ka hui carboxyl o glycine i elua hui pale tert-butoxycarbonyl no ka loaa ana o Boc-Gly-Gly-Gly-OH.

ʻIke palekana:

Pono ka hoʻohana ʻana iā Boc-Gly-Gly-Gly-OH i nā mea palekana e pili ana:

-E hōʻalo i ka pili ʻana me ka ʻili a me nā maka, no ka mea hiki ke hoʻonāukiuki i ka ʻili a me nā maka.

-E hoʻohana i nā mīkina lima pale kūpono, nā maka aniani a me nā lole pale i ka wā o ka hana.

-E hana ma kahi e hoʻoheheʻe maikaʻi ʻia e pale i ka hanu ʻana i kona lepo a i ʻole ka mahu.

-pono e mālama ʻia mai ke ahi, ka wela a me ka oxidant, e hoʻopaʻa paʻa i ka ipu, mālama ʻia ma kahi maloʻo a maloʻo.