Boc-N-beta-Trityl-L-asparagine (CAS# 132388-68-2)

Ka wehewehe palekana	S22 – Mai hanu i ka lepo. S24/25 – Hōʻalo i ka pili ʻana me ka ʻili a me nā maka.
WGK Kelemānia	3
HS Code	2924 29 70
Papa Hazard	HOOLAHA

ʻO NAA-tert-butoxycarbonyl N Γ-trityl aspartamide kahi mea hoʻohuihui, i ʻōlelo pinepine ʻia e ka pōkole Boc-Phe-OtBu. Loaʻa iā ia ke ʻano C30H37NO4 a he paʻa keʻokeʻo. Nature:
ʻO Boc-Phe-OtBu he hydrophobic a hiki ʻole ke hoʻoheheʻe ʻia i ka wai, akā hiki ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe kūlohelohe e like me ka methanol, ethanol a me dichloromethane. He kūpaʻa i ka māmā a me ka wela.

E hoʻohana:
Hoʻohana nui ʻia ʻo Boc-Phe-OtBu no ka pale ʻana i nā pūʻulu a me nā mea waena o ka hopena i ka synthesis organik. I ka synthesis, hiki ke hoʻohana ʻia e pale i nā waikawa amino aromatic, i ka synthesis o polypeptides a me nā protein, e pale ana i nā pūʻulu ikaika e pale i ka hanana ʻana o nā ʻaoʻao. Eia kekahi, hiki ke hoʻohana ʻia no ka hoʻomākaukau ʻana i nā mea hoʻohui ʻē aʻe, e like me nā lāʻau lapaʻau, nā mea hoʻonaninani a me nā mea kūlohelohe.

Kaʻina hoʻomākaukau:
ʻO ka hoʻomākaukau ʻana o Boc-Phe-OtBu i hoʻokō nui ʻia e ka hopena kemika. ʻO kekahi ʻano hana maʻamau, ʻo ia ka hana ʻana i ka waika p-benzoic me ka t-butyl hydroxyformate e hana ai i ka p-tert-butoxycarbonyl benzoate. Hoʻopili ʻia me ka triphenylamine e hāʻawi i ka huahana hope loa ʻo Boc-Phe-OtBu.

ʻIke palekana:
He palekana ka Boc-Phe-OtBu ma lalo o ka hoʻohana maʻamau. Eia nō naʻe, ma ke ʻano he kemika, pono e mālama ʻia a mālama pono ʻia. Hōʻalo i ka hoʻopili ʻana me nā oxidants ikaika, pale i ka inhalation o ka lepo a pale i ka pili ʻana i ka ʻili. I ka wā e hoʻohana ai, e ʻaʻahu i nā lako pale pilikino kūpono, e like me nā mīkina lima a me nā aniani pale. Inā loaʻa ka hoʻopili ʻana a i ʻole ka ʻai ʻana, e ʻimi koke i ka ʻōlelo aʻoaʻo olakino a hāʻawi i ka ʻike i ke kauka e pili ana i ke kemika. Pono e mālama ʻia nā lula palekana kūloko i ka wā e lawelawe ai a hoʻolei ʻana i ka ʻōpala.