Cbz-L-Glutamic acid 1-benzyl ester（CAS# 3705-42-8)
Hoʻolauna
ʻO Z-Glu-OBzl (Z-Glu-OBzl) he mea hoʻohui i hoʻohana mau ʻia ma ke ʻano he hui pale no nā waikawa amino. Eia ka wehewehe ʻana o nā waiwai, hoʻohana, hoʻomākaukau a me ka ʻike palekana o ka pūhui:
ʻAno:
-Ke kumu molekala: C17H17NO4
-Molecular kaumaha: 303.32g/mol
-Nani: ʻO ka pauka crystalline keʻokeʻo
-Lae hehee: 84-85°C
-Solubility: Hiki ke hoʻoheheʻe ʻia e like me ka dimethyl sulfoxide a me ka dimethylformamide
- Hiki ke wehe ʻia ka hui pale Cbz e ka palladium hydride catalyst ma lalo o nā kūlana acidic
E hoʻohana:
- ʻO Z-Glu-OBzl kahi pūʻulu pale o ka glutamic acid (Glu), hiki ke hoʻohana ʻia i ka synthesis o nā derivatives amino acid, polypeptides a me nā protein.
-Ma keʻano he pūʻulu pale no nā amino acids i loko o nā pūhui organik synthetic, hiki iā ia ke pale i ka pūʻulu amine o ka glutamic acid, pale iā ia mai ka hoʻopili ʻia e nā hopena kikoʻī ʻole, a hoʻomaʻamaʻa i ka wehe ʻana inā pono.
Kaʻina hoʻomākaukau:
-ʻO ka hoʻomākaukau ʻana o Z-Glu-OBzl ka mea maʻamau i kahi kaʻina hana multi-step a loaʻa i kahi ʻano o nā hopena kemika. ʻO kekahi o nā ala maʻamau ka pale mua ʻana i ka pūʻulu carboxyl o ka glutamic acid e like me ka t-butoxycarbonyl ester (Boc) a laila pale i ka hui amino e like me Cbz. ʻO ka mea hope loa, ua hoʻokumu ʻia ka huahana i makemake ʻia Z-Glu-OBzl e ka hopena me benzyl chloroformate.
ʻIke palekana:
- Pono e mālama ʻia ʻo Z-Glu-OBzl ma ke ʻano he mea hoʻonāukiuki a pale i ka hoʻopili pololei ʻana me ka ʻili a me nā maka.
-Ke hoʻohana ʻia i loko o ka hale hana, pono e hahai ʻia nā kaʻina hana palekana, me ke komo ʻana i nā aniani pale, nā mīkina lima a me nā ʻaʻahu hale hana.
- Pono e pale ʻia ka inhalation a i ʻole ka ʻai ʻana o ka pūhui a pono e lawe ʻia nā hana pale ahi a pahū i ka wā o ka mālama ʻana.
- Pono e hoʻokomo ʻia ka mea hoʻohui i loko o kahi wahi e hoʻoheheʻe maikaʻi ʻia i ka wā o ka hana ʻana, a pono e hoʻolei pono ʻia ka ʻōpala e like me nā lula kūloko.
