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dabigatran etexilate（CAS# 211915-06-9)
  • dabigatran etexilate（CAS# 211915-06-9) 1

dabigatran etexilate（CAS# 211915-06-9)

Waiwai Kemika:

ʻĀpana Molekala C34H41N7O5
Molar Mass 627.73
ʻO ka mānoanoa 1.24±0.1 g/cm3 (Wanamua)
Lae hehee 128-129°
Lae Boling 827.9°C ma 760 mmHg
Lae Flash 454.5°C
Ka hoʻoheheʻe DMSO (Lili iki), Methanol (Lili iki)
Puʻupuʻu mahu 1.49E-27mmHg ma 25°C
Ka nana aku Paʻa
kala kala Keʻokeʻo i ka Melemele Pale
pKa 9.88±0.46(Wanamua)
Kūlana Waihona Hoʻopaʻa ʻia i kahi maloʻo, E mālama i loko o ka paʻukū, ma lalo o -20 ° C
Paʻa Hygroscopic
Hōʻike Hōʻike 1.614
Haʻawina in vitro ʻO Dabigatran ke koho a hoʻohuli i ka thrombin kanaka (Ki: 4.5 nM) a me ka thrombin-induced platelet aggregation (IC50: 10 nM) a ʻaʻohe hopena pale i nā mea hoʻoulu platelet ʻē aʻe. Kāohi ʻo Dabigatran i ka hana ʻana o (PPP) thrombin i loko o ka plasma o nā platelets i hoʻopau ʻia me kahi IC50 o 0.56 μm e like me ke ana ʻana e ka endogenous thrombin Index (ETP). I loko o nā hoʻokolohua in vitro, loaʻa iā Dabigatran kahi hopena anticoagulant e hilinaʻi nei i nā ʻano like ʻole. I loko o ka PPP kanaka, ua pāpālua ʻia ka manawa thromboplastin ʻāpana i hoʻāla ʻia (aPTT), ka manawa prothrombin (PT) ma nā ʻano o 0.23,0.83 a me 0.18 μm, kēlā me kēia. A me ka Ecarin clotting time (ECT)..
In vivo haʻawina Dabigatran dose-dependently aPPT lōʻihi ma hope o intravenous administration i nāʻiole (0.3,1 a me 3 mg/kg) a me rhesus monkeys (0.15,0.3 a me 0.6 mg/kg). ʻO Dabigatran etexilate (20 mg/kg, PO) i hoʻolōʻihi i ka liʻiliʻi o ka waiwai k a me ka liʻiliʻi o ka attenuation o ka piʻi nui o nā puaʻa ma mua o ka enoxaparin. ʻO Dabigatran (0.01-0.1 mg / kg) i hoʻemi ʻia ma muli o ka thrombosis, me ED50 (50% hopena hopena) ʻo 0.033 mg / kg a me ka inhibition piha ma 0.1 mg / kg. ʻO ka Dabigatran etexilate (5-30 mg / kg) i kāohi i ka hoʻokumu ʻana o ka thrombus ma ke ʻano o ka hopena a me ka manawa e hilinaʻi ʻia, me ka nui o ka pale ʻana ma hope o 30 mau minuke o ka pretreatment, e hōʻike ana i kahi hopena wikiwiki.

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Hoʻolauna

ʻO ka Dibutyl phthalate kahi mea hoʻohuihui. He wai waihoʻoluʻu ʻole i ka melemele māmā me kahi ʻala kūikawā.

 

Hoʻohana nui ʻia ʻo Dabigatran etexilate ma ke ʻano he plasticizer. Hiki iā ia ke hoʻonui i ka palupalu a me ka ductility o nā plastics, no laila ua hoʻohana nui ʻia i ka hana ʻana i nā huahana plastic, e like me nā kiʻiʻoniʻoni plastik, nā paipu plastik, ka papahele plastik a me nā kāmaʻa plastik. Hiki ke hoʻohana ʻia i mea hoʻohui i nā solvents, lubricants a me nā mea ʻala.

 

Hoʻomākaukau pinepine ʻia ʻo Dabigatran etexilate e ka esterification o ka phthalic anhydride me ka n-butanol a i ʻole isobutanol. Hoʻokō ʻia ka hopena ma mua o kahi catalyst acid i ka mahana kūpono a me ke kaomi.

Hiki ke hoʻonāukiuki i ka ʻili a me nā maka a pono e holoi ʻia me ka wai nui ma hope koke o ka hoʻopili ʻana. Hōʻalo i ka hana ʻana me nā mea ʻokiʻekiʻe, pale i nā kumu hoʻāla a me ka haʻalele ʻana i nā wela kiʻekiʻe a me nā lapalapa ahi i ka wā o ka hana a me ka mālama ʻana. Pono e hoʻoheheʻe maikaʻi ʻia i ka wā e hoʻohana ai i mea e pale ai i ka hōʻiliʻili ʻana o ka mahu.

 

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