Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 )

Hoʻolauna

Eia ka hoʻolauna ʻana i nā waiwai, hoʻohana, nā ʻano hoʻomākaukau a me ka ʻike palekana o apixaban intermediate 3:

ʻAno maikaʻi:

ʻO Apixaban intermediate 3 kahi mea hoʻohuihui. He paʻa a hiki ke hoʻoheheʻe ʻia i nā solvents organik e like me ka ether a me ka ethyl acetate.

Hoʻohana: Hoʻohana maʻamau ia no ka maʻi maʻi anesthesia a me ka mālama ʻana i ka ʻeha nui.

Hanana:

ʻO ke ʻano o ka hoʻomākaukau ʻana o apixaban intermediate 3 hiki ke hoʻokō ʻia e nā ʻanuʻu aʻe: hoʻopili ʻia ka p-nitrobenzoic acid me ka hypobutylthiourea i ke alo o ka acetic acid a me ka thionyl chloride e loaʻa ai ka N-(p-nitrophenyl) -N-(hypobutylthioylurea) formic acid, a laila, hoʻopili me ka sodium hydroxide i ka sodium oxide a me ka methanol solution e loaʻa ai ka apixaban waena 3.

ʻIke palekana: Pono nā kaʻina hana palekana koʻikoʻi i ka hoʻohana ʻana a me ka lawelawe ʻana i kēia pūhui. Hiki ke hoʻopōʻino nui i ke olakino o ke kanaka ka pili pono ʻana a i ʻole ka inhalation. Pono e loiloi a hoʻoponopono ʻia kāna ʻike palekana e like me nā lula a me nā alakaʻi kūpono e hōʻoia i ka hoʻohana a me ka mālama pono ʻana. I ka hana ʻana i nā hoʻokolohua chemical synthesis, pono lākou e hana ʻia ma lalo o nā kūlana laboratory kūpono a pono e hoʻohana ʻia nā mea pale pilikino e like me nā maka aniani, nā mīkina lima pale, a me nā lole pale.