FMOC-Arg(Pbf)-OH (CAS # 154445-77-9)
Pilikia a palekana
| Nā hōʻailona pōʻino | Xi – Hoʻohaunaele |
| Nā Code Risk | 36/37/38 – Hoʻonanea i nā maka, ʻōnaehana hanu a me ka ʻili. |
| Ka wehewehe palekana | S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. S36 – E komo i nā lole pale kūpono. |
| WGK Kelemānia | 1 |
| HS Code | 2935 90 90 |
| Papa Hazard | HOOLAHA |
Hoʻolauna
ʻO ka pūʻulu pale FMOC he hui pale amino acid i hoʻohana mau ʻia e pale i ka pūʻulu hana amino o arginine. ʻO kēia ka hoʻolauna ʻana i kekahi o nā waiwai, hoʻohana, nā ʻano hoʻomākaukau, a me ka ʻike palekana o ka Fmoc-Protective Radical.
ʻAno maikaʻi:
ʻO ka hui pale FMOC he pūʻulu pale e hiki ke hoʻoneʻe ʻia e pale i nā hui amino amino. Hiki iā ia ke hana me ka hui amino i ka arginine ma o ka esterification reaction e hana ai i ka Fmoc-arginine ester, i mea e hoʻokō ai i ke kumu o ka pale ʻana i ka hui amino. Aia nā pūʻulu aromatic ma ka molekala hui pale-Fmoc e hoʻopaʻa ikaika i ke kukui UV, kahi e hiki ai ke hoʻoneʻe ʻia o ka pūʻulu pale Fmoc e lawe ʻia e ka UV irradiation a i ʻole nā hana kemika.
E hoʻohana:
Hoʻohana nui ʻia nā hui pale FMOC i ka synthesis peptide a me ka synthesis solid-phase. Hiki iā ia ke pale pono i ka pūʻulu amino arginine e pale i kāna ʻaoʻao ʻaoʻao i ka wā synthesis. I ka peptide synthesis, hiki ke hoʻoneʻe ʻia ka hui pale Fmoc e nā kūlana alkaline, e ʻae i ka synthesis o polypeptides e hoʻomau.
Hanana:
Hiki ke hoʻomākaukau ʻia ka hui pale Fmoc e ka hopena o Fmoc-Cl a me arginine. ʻO ka Fmoc-Cl kahi mea hoʻoheheʻe ʻakika ikaika e hana me ka hui amino i ka arginine e hana i ka Fmoc-arginine ester. Hoʻokō pinepine ʻia ka hopena i ka ethanol i ka mahana ʻauʻau hau.
ʻIke palekana:
Mālama ʻia ka FMOC-Protective Radicals e hoʻohana ma lalo o nā kūlana hana maʻamau, akā pono e hoʻomaopopo ʻia kēia mau mea:
- ʻO FMOC-CL kahi mea hoʻonāukiuki a me nā mea ʻawaʻawa, pono e mālama ʻia e pale aku i ka pili ʻana me ka ʻili, inhalation a i ʻole ingestion. E hana ma kahi e hoʻoheheʻe maikaʻi ʻia a hoʻokomo i nā lako pale pilikino kūpono.
- Loaʻa i ka FMOC-Protective Base ka waiwai o ka absorption ikaika o nā kukuna ultraviolet, no laila e mālama pono e pale i ka hoʻopili pololei ʻana me ka ʻili a me nā maka i ka wā o ka hoʻohana ʻana, a mālama i nā kumu kukui ikaika.
- Hoʻohana pinepine ʻia ka pale hydrolysis acid ikaika e like me ka pentafluorophenylcarboxylic acid (TFA) i ka wā o ka wehe ʻana i nā pūʻulu pale-Fmoc, a pono e ʻike ʻia hiki ke hoʻopōʻino ka mahu o TFA, no laila pono e hana i loko o kahi pūnāwai. wahi ea.
