fmoc-O-tert-butyl-D-tyrosine (CAS# 118488-18-9)

ʻO Fmoc-O-tert-butyl-D-tyrosine kahi ʻakika amino i hoʻohana mau ʻia. ʻO kēia ka wehewehe ʻana o kona ʻano, hoʻohana, hana a me ka ʻike palekana:

ʻAno:
ʻO Fmoc-O-tert-butyl-D-tyrosine kahi paʻa keʻokeʻo keʻokeʻo. He pūhui mea ola ia me ke kumu kemika C30H31NO7 a me ke kaumaha molekala o 521.57g/mol. ʻO ka pūhui he mea ia o ka tyrosine i loko o ka pūʻulu amino e lawe i kahi pūʻulu pale Fmoc (9-fluorofluorenylformyl) a ʻo ka hui carboxylic acid e esterified me O-tert-butyl.

E hoʻohana:
Hoʻohana mau ʻia ʻo Fmoc-O-tert-butyl-D-tyrosine ma ke ʻano he amino acid i pale ʻia i ka peptide synthesis. Ma ka hoʻopili ʻana i ka pūʻulu pale Fmoc i ka hui amino, hiki ke pale ʻia nā hopena ʻaoʻao makemake ʻole i ka wā o ka synthesis. Hoʻohana nui ʻia ia i ka synthesis paʻa paʻa a hiki ke hoʻohana ʻia e synthesize polypeptides a me nā protein.

Kaʻina hoʻomākaukau:
Hana ʻia ka hoʻomākaukau ʻana o Fmoc-O-tert-butyl-D-tyrosine e ka synthesis kemika. ʻO ka mua, hoʻopili ʻia ka tyrosine me Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) e hana ai i ka Fmoc-O-tyrosine. Hoʻohui ʻia ʻo Cesium tert-butyl bromide i ka hopena e esterify i ka hui ʻakika carboxylic e hana i Fmoc-O-tert-butyl-D-tyrosine. ʻO ka hope loa, loaʻa ka huahana maʻemaʻe e nā ʻanuʻu o ka crystallization, ka holoi ʻana a me ka maloʻo.

ʻIke palekana:
ʻO Fmoc-O-tert-butyl-D-tyrosine kahi pūhui paʻa ma lalo o nā kūlana maʻamau a ʻaʻohe volatilization maopopo i ka wela lumi. I ka wā o ka hoʻohana ʻana, pono e hoʻokō i nā kaʻina hana palekana lab, e hoʻohana i nā lako pale kūpono, a pale i ka pili ʻana me ka ʻili a me nā maka. I ka lawelawe ʻana a mālama ʻana paha, pono e mālama ʻia ma kahi maloʻo a maʻalili a mamao mai ke ahi a me nā mea hoʻoheheʻe. I ka manawa like, pono e pale ʻia ka launa pū ʻana me nā oxidants ikaika a me nā ʻakika ikaika i mea e pale ai i nā hopena pōʻino. E ʻimi koke i ke kōkua lapaʻau inā ʻai ʻia a ʻike ʻole ʻia paha i ka pūhui.