fmoc-L-4-hydroxyproline（CAS# 88050-17-3)

Hoʻolauna

ʻO ka Fmoc-L-hydroxyproline (Fmoc-Hyp-OH) he ʻakika amino derivative me nā waiwai a me nā hoʻohana:

ʻAno maikaʻi:

- Ke ʻano: ʻO ka pauka crystalline keʻokeʻo a keʻokeʻo paha

- Solubility: Hiki ke hoʻoheheʻe ʻia e like me DMF, DMSO a me ka methanol

- Waiwai pKa: 2.76

E hoʻohana:

- Hoʻohana nui ʻia ʻo Fmoc-Hyp-OH no ka peptide synthesis a me ka peptide synthesis i ka solid-phase synthesis

- He ʻāpana ia o ka pūʻulu pale e pale i nā pūʻulu hana ʻaoʻao ʻaoʻao o nā waikawa amino i ka wā synthesis solid-phase e pale aku i nā hopena i manaʻo ʻole ʻia a mālama i ka koho.

Hanana:

Hiki ke hoʻomākaukau ʻia ka Fmoc-Hyp-OH ma ka hana ʻana i nā waikawa Fmoc-amino me L-hydroxyproline i loko o kahi mea hoʻoheheʻe kūpono. ʻO nā kūlana hoʻololi maʻamau e loaʻa i kahi wela hoʻonā kūpono a me kahi mea hoʻoheheʻe kumu kūpono, e like me N,N-dimethylpyrrolidone (DMAP). Hoʻomaʻemaʻe ʻia ka huahana e nā ʻanuʻu e like me ka ua, ka holoi ʻana, a me ka maloʻo.

ʻIke palekana:

- ʻO ka FMOC-HYP-OH kahi hui kūlohelohe a pono e mālama ʻia e like me nā kaʻina palekana palekana.

- Hiki ke hanu ʻia ka lepo a hoʻopili ʻia me ka ʻili, no laila pono e mālama ʻia e pale i ka inhalation a i ʻole ka pili ʻana.

- I ka wā o ke kaʻina hana, pono e ʻaʻahu ʻia nā lako pale pilikino e like me nā mīkina lima laboratory, ka pale maka, nā lole pale, a me nā mea ʻē aʻe.

- Pono e mālama ʻia me ka sila paʻa i kahi maloʻo a maʻalili, ma kahi mamao o ke ahi a me nā mea hiki ke ahi.