Fmoc-O-trityl-L-serine (CAS # 111061-56-4)

Hoʻokomo ʻia ʻo Fmoc-O-trityl-L-serine (CAS # 111061-56-4), he poloka hale no ka peptide synthesis i hoʻolālā ʻia e hoʻokiʻekiʻe i kāu mau noiʻi a me nā papahana hoʻomohala i nā kiʻekiʻe hou. He mea nui kēia pūhui hoʻomaʻemaʻe kiʻekiʻe no nā chemists a me nā biochemists e nānā ana e hana i nā peptides paʻakikī me ka pololei a me ka pono.

ʻO Fmoc-O-trityl-L-serine kahi ʻano pale o ka amino acid serine, e hōʻike ana i kahi hui kūʻokoʻa o Fmoc (9-fluorenylmethoxycarbonyl) a me trityl (Tr) pūʻulu pale. ʻAʻole kēia hoʻolālā pale ʻelua e hoʻonui i ka paʻa o ke koena serine i ka wā synthesis akā hiki nō hoʻi i ka deprotection koho, e lilo ia i koho kūpono no ka solid-phase peptide synthesis (SPPS). Hoʻomaʻamaʻa ka hui Fmoc i ka wehe maʻalahi ma lalo o nā kūlana maʻalahi, aʻo ka hui trityl e hāʻawi i ka pale hou aku i nā ʻaoʻao i makemake ʻole ʻia.

Me ka molecular formula o C27H29NO4 a me ka molecular kaumaha o 433.53 g / mol, Fmoc-O-trityl-L-serine ua hōʻike ʻia e kona solubility kiʻekiʻe i loko o nā mea hoʻoheheʻe organik, e hoʻolilo iā ia i mea maʻalahi no nā noi synthetic. ʻO kona maʻemaʻe maikaʻi loa e hōʻoia i kāu huahana peptide hope loa o ke ʻano kiʻekiʻe loa, me ka ʻole o nā haumia e hiki ke hoʻololi i kāu mau hopena noiʻi.

Inā ʻoe e hoʻomohala nei i nā peptides therapeutic, ke aʻo ʻana i nā pilina protein, a i ʻole e ʻimi ana i nā moho lāʻau lapaʻau hou, ʻo Fmoc-O-trityl-L-serine ka koho hilinaʻi no kāu pono synthesis. Hoʻāʻo ikaika ʻia kā mākou huahana a hele mai me nā palapala piha e kākoʻo i kāu mau hana noiʻi.

Wehe i ka hiki o kāu peptide synthesis me Fmoc-O-trityl-L-serine. E ʻike i ka ʻokoʻa i hiki i nā reagents kiʻekiʻe ke hana i kāu keʻena keʻena. E kauoha i kēia manawa a e hana i ka hana mua i ka hoʻokō ʻana i kāu mau pahuhopu ʻepekema me ka hilinaʻi!