L-Pyroglutamic acid CAS 98-79-3
Pilikia a palekana
| Nā hōʻailona pōʻino | Xi – Hoʻohaunaele |
| Nā Code Risk | 36/37/38 – Hoʻonanea i nā maka, ʻōnaehana hanu a me ka ʻili. |
| Ka wehewehe palekana | S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. S36 – E komo i nā lole pale kūpono. S37/39 – E hoʻohana i nā mīkina lima kūpono a me ka pale maka/maka |
| WGK Kelemānia | 3 |
| RTECS | TW3710000 |
| NUI FLUKA BRAND F | 21 |
| TSCA | ʻAe |
| HS Code | 29337900 |
| Hoʻolauna | ʻO ka pyroglutamic acid ka 5-oxyproline. Hoʻokumu ʻia ia e ka dehydration ma waena o ka pūʻulu α-NH2 a me ka pūʻulu γ-hydroxyl o ka waikawa glutamic e hana i kahi paʻa lactam mole; Hiki ke hana ʻia ma ka lilo ʻana o kahi pūʻulu Amido i loko o kahi mole glutamine. Inā nele ka glutathione synthetase, hiki ke hoʻoulu i ka pyroglutamemia, kahi ʻano o nā hōʻailona lapaʻau. ʻO ka Pyroglutamemia kahi maʻi o ka metabolism acid organik i hoʻokumu ʻia e ka hemahema o ka glutathione synthetase. Nā hōʻike maʻi o ka hānau ʻana 12 ~ 24 hola o ka hoʻomaka ʻana, holomua hemolysis, jaundice, maʻi Metabolic Acidosis, nā maʻi noʻonoʻo, etc.; Aia ka mimi i ka waika pyroglutamic, ka waikawa lactic, Alpha deoxy4 glycoloacetic acid lipid. Hoʻomaʻamaʻa, symptomatic, e hoʻolohe i ka hoʻoponopono ʻana i ka meaʻai ma hope o ka makahiki. |
| waiwai | L-pyroglutamic acid, i ʻike ʻia ʻo L-pyroglutamic acid, L-pyroglutamic acid. Mai ka ethanol a me ka petroleum ether hui i ka ua o colorless orthorhombic double cone Crystal, hehee wahi o 162 ~ 163 ℃. Hiki ke hoʻoheheʻe ʻia i ka wai, ka waiʻona, ka acetone a me ka acetic acid, ethyl acetate-soluble, insoluble in ether. ʻO ka hoʻololi ʻike kikoʻī -11.9 °(c = 2,H2O). |
| Nā hiʻohiʻona a me nā hoʻohana | Aia i loko o ka ʻili o ke kanaka kahi hana moisturizing o nā mea hiki ke hoʻoheheʻe ʻia i ka wai-ka mea hoʻomaʻemaʻe kūlohelohe, ʻo kona ʻano he amino acid (40%), pyroglutamic acid (12%), nā paʻakai inorganic (Na, K, Ca, Mg, etc. loaʻa iā 18.5%), a me nā mea hoʻohui ʻē aʻe (loaʻa ka 29.5%). No laila, ʻo ka pyroglutamic acid kekahi o nā mea nui o ka mea hoʻomaʻemaʻe kūlohelohe o ka ʻili, a ʻoi aku kona hiki ke hoʻomaʻemaʻe ma mua o ka glycerol a me propylene glycol. A ʻaʻohe mea ʻawaʻawa, ʻaʻohe mea hoʻoulu ʻia, kahi mālama ʻili hou, nā mea hoʻonaninani lauoho lauoho maikaʻi loa. He hopena pale ka Pyroglutamic acid i ka hana o ka tyrosine oxidase, ma laila e pale ai i ka waiho ʻana o nā mea "melanoid" i loko o ka ʻili, he hopena keʻokeʻo i ka ʻili. Loaʻa ka hopena palupalu i ka ʻili, hiki ke hoʻohana ʻia no nā mea hoʻonaninani nail. Ma waho aʻe o ka hoʻohana ʻana i nā mea hoʻonaninani, hiki i ka L-pyroglutamic acid ke hana i nā derivatives me nā pūhui organik ʻē aʻe, i loaʻa nā hopena kūikawā i ka hana o ka ʻili, ka ʻike a me ka ʻālohilohi, a me nā mea ʻē aʻe. ʻO nā reagents kemika no ka hoʻonā ʻana i nā amine racemic; Nā mea waena maʻamau. |
| ʻano hoʻomākaukau | Hoʻokumu ʻia ka waikawa L-pyroglutamic ma ka wehe ʻana i hoʻokahi minuke o ka wai mai ka mole o ka L-glutamic acid, a maʻalahi kāna kaʻina hana, ʻo nā ʻanuʻu koʻikoʻi ka mana o ka mahana a me ka manawa dewatering. (1) 500g o ka L-glutamic acid i hoʻohui ʻia i ka 100 ml beaker, a ua wela ka beaker me ka ʻauʻau aila, a ua hoʻokiʻekiʻe ʻia ka mahana i 145 a i 150 ° C., a mālama ʻia ka mahana no 45 mau minuke no ka dehydration. pane ʻana. ʻO ka wai hoʻoheheʻe ʻia ʻo Tan. (2) ma hope o ka pau ʻana o ka hopena dehydration, ua ninini ʻia ka hopena i loko o ka wai paila me ka nui o 350, a ua hoʻoheheʻe ʻia ka hopena i ka wai. Ma hope o ka hoʻoluʻu ʻana i 40 a 50 ° C., ua hoʻohui ʻia kahi nui kūpono o ke kalapona i hoʻāla ʻia no ka decoloration (e hana hou ʻia ʻelua). Ua loaʻa kahi hāʻina ʻākala kala ʻole. (3) i ka wā i hoʻomaʻamaʻa pono ʻia ai ka hoʻonā ʻulaʻula ʻole i hoʻomākaukau ʻia ma ka ʻanuʻu (2) e hoʻemi i ka leo i ka hapalua, huli i ka ʻauʻau wai a hoʻomau i ka noʻonoʻo ʻana i ka nui o kahi 1/3, hiki iā ʻoe ke hoʻōki i ka hoʻomehana ʻana, a ma ka ʻauʻau wai wela e lohi i ka crystallization, 10 a 20 mau hola ma hope o ka hoʻomākaukau ʻana i nā kristal prismatic colorless. ʻO ka nui o ka L-pyroglutamic acid i loko o nā mea hoʻonaninani e pili ana i ka hoʻokumu ʻana. Hiki ke hoʻohana ʻia kēia huahana i nā mea hoʻonaninani ma ke ʻano o 50% concentrated solution. |
| ʻakika glutamic | ʻO ka glutamic acid he ʻakika amino i hoʻokumu ʻia he protein, he kaulahao ʻaoʻao ʻakika ionized, a hōʻike i ka hydrotropism. Hiki i ka ʻakika glutamic ke cyclization i loko o ka pyrrolidone carboxylic acid, I.e., pyroglutamic acid. He kiʻekiʻe loa ka glutamic acid i nā protein cereal a pau, e hāʻawi ana i ka alpha-ketoglutarate ma o ka pōʻai tricarboxylic acid. Hiki ke hoʻopili pololeiʻia ka alpha ketoglutaric acid mai ka ammonia ma lalo o ka catalysis o ka glutamate dehydrogenase a me ka NADPH (coenzyme II), a hiki ke hoʻopiliʻia e ka aspartate aminotransferase a iʻole ka alanine aminotransferase, hanaʻia ka glutamic acid e ka transamination o ka aspartic acid a iʻole alanine; Eia kekahi, hiki ke hoʻololi hou ʻia ka glutamic acid me ka proline a me ka ornithine (mai ka arginine). No laila, ʻo Glutamate kahi waikawa amino pono ʻole. Ke hoʻokaʻawale ʻia ka glutamic acid ma lalo o ka catalysis o ka glutamate dehydrogenase a me NAD (coenzyme I) a i ʻole e hoʻoneʻe ʻia i waho o ka hui amino ma lalo o ka catalysis o aspartate aminotransferase a i ʻole alanine aminotransferase e hana i ka alpha ketoglutarate, komo ia i ka pōʻai tricarboxylic acid a hoʻopuka i nā kō ma o ka ʻO ke ala gluconeogenic, no laila, he mea nui ka waikawa amino glycogenic. Hiki i ka glutamic acid i nā ʻiʻo like ʻole (e like me ka ʻiʻo, ka ate, ka lolo, a me nā mea ʻē aʻe) hiki ke synthesize i ka glutamine me NH3 ma o ka catalysis o glutamine synthetase, ʻo ia ka huahana detoxification o ka amonia, ʻoi aku hoʻi i ka ʻiʻo o ka lolo, a me ke ʻano o ka mālama ʻana a me ka hoʻohana ʻana. ammonia i loko o ke kino (e nānā i ka "glutamine a me kāna metabolism"). Hoʻohui ʻia ka glutamic acid me ka acetyl-CoA ma ke ʻano he cofactor o ka mitochondrial carbamoyl phosphate synthase (i komo i ka synthesis o ka urea) ma o ka catalysis o ka acetyl-glutamate synthase. ʻO ka γ-aminobutyric acid (GABA) he huahana ia o ka decarboxylation o ka glutamic acid, ʻoi aku ka nui o ka nui o ka nui o ka lolo, a ʻike pū ʻia hoʻi i loko o ke koko, ʻo kāna hana physiological i manaʻo ʻia he neurotransmitter inhibitory, nā hopena antispasmodic a me hypnotic i hana ʻia e ka Hiki ke hoʻokō ʻia ka infusion clinical o echinocandin ma o GABA. Hoʻokomo ka catabolism o GABA i ka pōʻai tricarboxylic acid ma o ka hoʻololi ʻana i ka GABA transaminase a me ka aldehyde dehydrogenase i ka waikawa succinic e hana i kahi shunt GABA. |
| Hoʻohana | hoʻohana ʻia e like me nā intermediates i ka synthesis organik, nā meaʻai meaʻai, etc. hoʻohana ʻia i ka meaʻai, ka lāʻau lapaʻau, nā mea hoʻonaninani a me nā ʻoihana ʻē aʻe |
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