Methyl 2-cyanoisonicotinate（CAS# 94413-64-6)
Pilikia a palekana
| Papa Hazard | 6.1 |
Hana hana
ua hoʻomākaukau ʻia ka pūhui pahuhopu e ka oxidation, amidation a me ka dehydration me ka methyl 2-methyl 4-pyridinecarboxylate (2) i mea hoʻomaka. ua hōʻoia ʻia kona ʻano e 1H NMR a me MS, a ʻo ka huina o ka hua he 53.0%. Ua aʻo ʻia nā hopena o ka lākiō hānai, ka mahana crystallization, ka manawa pane a me nā mea ʻē aʻe i ka huahana e nā hoʻokolohua hoʻokahi-factor, a ua hoʻopaʻa ʻia nā kūlana kaʻina: n(2): n (potassium permanganate) = 1.0:2.5, crystallization temperature 0 ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0:1.4, pane; ʻO ka hopena dehydration e koho i ka trifluoroacetic anhydride-triethylamine system e like me ka mea hoʻoheheʻe wai. He maʻalahi ke kaʻina hana, ʻoluʻolu nā kūlana pane, maʻalahi e hoʻonui i ka hana, a he waiwai hoʻohana kūpono.
Hoʻohana
Hoʻohana ʻia ʻo Tobisostat e mālama i ka hyperuricemia mau o ka gout. Ke hoʻohālikelike ʻia me ka allopurinol lāʻau lapaʻau maʻamau (purine analog), ʻaʻole ia e hoʻopilikia i ka purine a me ka pyridine metabolism a me ka hana enzyme, a hoʻemi ia i ka uric acid ʻOi aku ka ikaika o ka hopena, ʻaʻole pono ka hoʻoponopono hou ʻana i ka nui, a ʻoi aku ka maikaʻi o ka palekana. ʻO Methyl 2-cyano-4-pyridine carboxylate kahi mea waiwai nui no ka synthesis o Tobiso.
