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Mitotan(CAS# 53-19-0)

Waiwai Kemika:

ʻĀpana Molekala C14H10Cl4
Molar Mass 320.04
ʻO ka mānoanoa 1.3118 (manaʻo koʻikoʻi)
Lae hehee 77-78°C(māmā)
Lae Boling 405.59°C (manaʻo koʻikoʻi)
Hiki i ka wai <0.1 g/100 mL ma 24 ºC
Ka hoʻoheheʻe DMSO: soluble20mg/mL, akaka
Ka nana aku pauda
kala kala keʻokeʻo i ka beige
ʻO Merck 13,6237 / 13,6237
BRN 2056007
Kūlana Waihona Ka lewa inert, ka wela lumi
Hōʻike Hōʻike 1.6000 (manaʻo)
Na Waiwai Kino a Kimia Ka helu hehee 76-78°C
hiki ke hoʻoheheʻe ʻia i ka wai <0.1g/100 mL ma 24°C
Hoʻohana No ka noiʻi ʻepekema wale nō kēia huahana a ʻaʻole e hoʻohana ʻia no nā kumu ʻē aʻe.
Haʻawina in vitro I loko o ka laina kelepona TalphaT1 kiole, ua kāohi ʻo Mitotane i ka hōʻike ʻana a me ka huna ʻana o TSH, poloka i ka pane ʻana o TSH i TRH, a hoʻemi i ka viability cell, a hoʻoulu i ka apoptosis. I loko o ka pituitary TSH-secreting kiole pūnaewele, Mitotane 'aʻole keakea i ka thyroid hormone, akā, ho'ēmi pololei i ka hana huna a me ka ola ola. Hoʻokomo ʻo Mitotane i ka necrosis cortical adrenal, ka pōʻino o ka membrane mitochondrial, a me ka paʻa ʻole ʻana i ka protein CYP. ʻO ka Mitotane (10-40 μm) i kāohi i ka basal a me ka cAMP-induced cortisol huna akā ʻaʻole i make ka cell cell. Ua hōʻike ʻo Mitotane i nā hopena inhibitory ma nā protein basal StAR a me P450scc. ʻO ka Mitotane (40 μm) i hoʻemi nui i nā pae mRNA o StAR, CYP11A1 a me cyp21. ʻO ka Mitotane (40 μm) aneane hoʻopau loa i ka induction o STAR, CYP11A1, CYP17, a me CYP21 mRNA e adenosine 8-bromo-cyclic phosphate. Ma ka māhele S o nā pūnaewele H295R,ʻo ka hui pūʻana o Mitotane a me gemcitabine i hōʻike i ka antagonism a hoʻopilikia i ka gemcitabine-mediated inhibition i ka pōʻai pūnaewele.
In vivo haʻawina I nā ʻiole, ua hoʻemi nui ʻo Mitotane (60 mg / kg) i ka mitochondrial adrenal a me ka microsomal "P-450" a me nā protein microsomal e 34%,55% a me 35%.

Huahana Huahana

Huahana Huahana

Nā hōʻailona pōʻino Xn – Poino
Nā Code Risk 40 - Nā hōʻike liʻiliʻi o kahi hopena carcinogenic
Ka wehewehe palekana 36/37 - E hoʻohana i nā lole pale kūpono a me nā mīkina lima.
UN ID 3249
WGK Kelemānia 3
RTECS KH7880000
HS Code 2903990002
Papa Hazard 6.1(b)
Hui Pūʻulu III

 

Hoʻolauna

ʻO ka Mitotane kahi pūhui olaola me ka inoa kemika N, N'-methylene diphenylamine. ʻO kēia ka hoʻolauna ʻana i nā waiwai, hoʻohana, nā ʻano hoʻomākaukau a me ka ʻike palekana o ka mitotane:

 

ʻAno maikaʻi:

- ʻO ka Mitotane kahi paʻa kalakala kala ʻole i hiki ke hoʻoheheʻe ʻia i loko o nā mea hoʻoheheʻe kūlohelohe e like me ka ethanol, ether, a me ka chloroform.

- He pilau ikaika ko Mitotane.

 

E hoʻohana:

- Hoʻohana nui ʻia ʻo Mitotane no ka hoʻopili ʻana i nā hopena i ka synthesis organik a hoʻohana pinepine ʻia e like me ka reagent a me ka catalyst.

- Hiki iā ia ke komo i nā ʻano hopena kemika, e like me ka hui ʻana o nā alkynes, alkylation o nā mea ʻala, a pēlā aku.

 

Hanana:

- Hiki ke hoʻohui ʻia ʻo Mitotane e ka hopena ʻelua. Hoʻopili ʻia ka formaldehyde me ka diphenylamine ma lalo o nā kūlana alkaline e hana i ka N-formaldehyde diphenylamine. A laila, ma ka pyrolysis a i ʻole ka hoʻomalu ʻana i ka hoʻonā ʻana, ua hoʻololi ʻia i mitotane.

 

ʻIke palekana:

- He mea hoʻonāukiuki ka Mitotane a ʻaʻole pono e hoʻopili pololei me ka ʻili a me nā maka. Pono e ʻaʻahu ʻia nā mea pale kūpono e like me nā mīkina lima, nā maka aniani, a me nā lole pale i ka wā e hana ai.

- I ka mālama ʻana a me ka mālama ʻana, e mālama pono i ka sila a me ka pale ʻana mai ka mālamalama e pale aku i ka pili ʻana me ka ea a me ka wai.

- Hoʻoheheʻe ʻia ʻo Mitotane i nā wela kiʻekiʻe e hana i nā kinoea ʻawaʻawa, pale i ka wela a i ʻole ka hoʻopili ʻana me nā mea ʻē aʻe.

- E nānā i nā hoʻoponopono kūloko a hahai i nā kaʻina hana palekana kūpono i ka wā e hoʻolei aku ai iā lākou.


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