N-Boc-N'-tosyl-D-histidine（CAS# 69541-68-0)
Hoʻolauna
ʻO Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) he mea kemika nona nā waiwai penei:
ʻAno:
1. Nānā: paʻa keʻokeʻo
2. kumu mole: C21H25N3O6S
3. ke kaumaha mole: 443.51
4. Heheʻe wahi: ma kahi o 110-115 ° C
E hoʻohana:
Hoʻohana mau ʻia ʻo Boc-D-His(Tos)-OH i ka synthesis organik ma ke ʻano he hui pale no D-histidine (D-His). ʻO kāna mau hoʻohana nui he:
1. I ka synthesis o kahi polypeptide, hoʻohana ʻia ia e synthesize i kahi kaʻina polypeptide i loaʻa kahi hui pale D-histidine.
2. Hoʻohana ʻia ma ke ʻano he mea waena ma ke kahua o ka lāʻau kemika no ka hoʻohui ʻana i nā pūhui pahuhopu biologically active.
3. Ka hoʻolālā a me ka hoʻohui ʻana i nā hui moho lāʻau i ka noiʻi.
Kaʻina hoʻomākaukau:
Hana ʻia ka hoʻomākaukau ʻana o Boc-D-His(Tos)-OH e nā ʻanuʻu aʻe:
1. Hoʻopili ʻia ka D-histidine (D-His) me ka p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) e hāʻawi iā D-histidine p-toluenesulfonyl (D-His-Tos).
2. Ma lalo o nā kūlana alkaline, hoʻopili ʻia ʻo D-His-Tos me ka n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) e hoʻohua i ka Boc-D-His(Tos)-OH.
ʻIke palekana:
Ua kaupalena ʻia ka loiloi palekana o Boc-D-His(Tos)-OH, akā ma ke ʻano he mea kemika, pono e ʻike ʻia kēia mau mea palekana:
1. E pale i ka inhalation, pili me ka ili a me na maka. E hoʻohana i nā lako pale pilikino kūpono, e like me nā mīkina lima a me nā aniani.
2. Pono e hahai ʻia nā hana hoʻokolohua maikaʻi i ka wā o ka hoʻohana ʻana a pono e hōʻoia i nā kūlana ea.
3. E mālama i loko o kahi pahu i hoʻopaʻa ʻia, ma kahi mamao o ke ahi a me ka oxidant.
4. E hahai i nā hoʻoponopono kūpono a me nā alakaʻi i ka wā e hana ai.
Ke hoʻohana nei i ka Boc-D-His(Tos)-OH, e ʻoluʻolu e hahai i nā lula palekana a me nā ʻōlelo aʻoaʻo e pili ana i ka hana, a mālama pono a mālama pono i nā kemika. Inā pono, ua ʻōlelo ʻia e hana ma lalo o ke alakaʻi a nā poʻe loea.
