N-Cbz-L-Threonine（CAS# 19728-63-3)
Pilikia a palekana
| Nā hōʻailona pōʻino | Xn – Poino |
| Nā Code Risk | R20/21/22 – He pōʻino ma ka inhalation, pili me ka ʻili a inā ale ʻia. R36/37/38 – Hoʻonanea i ka maka, ka ʻōpū hanu a me ka ʻili. |
| Ka wehewehe palekana | S22 – Mai hanu i ka lepo. S24/25 – Hōʻalo i ka pili ʻana me ka ʻili a me nā maka. S36 – E komo i nā lole pale kūpono. S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. |
| WGK Kelemānia | 3 |
| HS Code | 29242990 |
N-Cbz-L-Threonine（CAS# 19728-63-3) ʻIkepili
| hoomakaukau ana | hoʻohui i 50mL o L-Thr(30mmol) a hoʻoluʻu ʻia i loko o ka ʻōmole hopena 250mL, a hoʻoulu a hoʻoheheʻe ʻia i loko o ka ʻauʻau hau. Hoʻokuʻu i 20mL o Z-OSu(39.4mmol) acetone solution i loko o ka ʻōmole hopena; E hoʻoulu i ka hopena ma 25 ℃, TLC-UV fluorescence a me ke ʻano kala ninhydrin e nānā i ke kaʻina hana. Ma hope o ka hopena, e hoʻohui i ka H2O20mL, e unuhi me Et2O(30mL × 2) ma ka pH>9, e hōʻiliʻili i ka pae wai, e hoʻoponopono i ka pH i 3 ~ 4 me 1.5NHCl, e unuhi me EtOAc (30mL × 3), e hui i ka pae organik, holoi me ka solution NaCl saturated (25mL × 2), maloo me Na2SO4 anhydrous, e nana i ka maemae e TLC-ultraviolet fluorescence a me ninhydrin waihoʻoluʻu hana hoʻomohalaʻano, a evaporate ma lalo o emi puʻe, maloo maloo e loaa i ka yellowish oily wai N-benzyloxycarbonyl-L-threonine, i mālama 'ia ma haʻahaʻa wela. |
| Hoʻohana | ʻO CBZ-L-threonine ka ʻano pale N-Cbz o L-threonine (T405500). ʻO ka L-threonine kahi waikawa amino koʻikoʻi a hoʻohana mau ʻia ma ke ʻano he meaʻai a me ka meaʻai. ʻO ka mutant strain o Escherichia coli i hana i ka nui o ka L-threonine no ka noiʻi a me ka meaʻai meaʻai. Loaʻa maoli ka L-threonine i ka iʻa a me ka moa a ua hoʻokomo ʻia i loko o kekahi o nā protein koʻikoʻi o ke kino, e like me ka hemoglobin a me ka insulin. Hoʻohana ʻia no nā reagents biochemical a me ka synthesis peptide. |
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