Ke kū nei nā ʻano i loko o ka mākeke 3,5-di-tert-butyl-4-hydroxybenzaldehyde: ʻO nā kikowaena lāʻau lapaʻau ma United States a me ʻEulopa

ʻO ke koi o ka ʻoihana lāʻau lapaʻau no nā mea waena kiʻekiʻe, pono no ka synthesis o nā pūhui therapeutic like ʻole, ua ulu nui i nā makahiki i hala. Ma waena o kēia mau mea waena, 3,5-di-tert-butyl-4-hydroxybenzaldehyde (CAS#1620-98-0) ua lilo i mea pāʻani nui ma nā mākeke US a me ʻEulopa. ʻIke ʻia no kāna mau waiwai kemika kūikawā a me ka versatility, hoʻohana nui ʻia kēia pūhui i ka hana ʻana i nā lāʻau lapaʻau, agrochemical a me nā kemika kūikawā.

ʻO 3,5-di-tert-butyl-4-hydroxybenzaldehyde ka mea i ʻike mua ʻia no kāna kuleana ma ke ʻano he lāʻau lapaʻau waena. ʻO ia ka mea kumu no ka synthesis o nā mea lāʻau lapaʻau ikaika (API), ʻoi aku ka nui o nā mea i hoʻohana ʻia e mālama i nā maʻi maʻi e like me ke kanesa, ka maʻi cardiovascular, a me ka metabolic syndrome. ʻO ka hiki o ka hui ke hoʻonui i ka pono a me ka paʻa o nā mea hana lāʻau lapaʻau ua lilo ia i mea ʻimi ʻia no nā mea hana lāʻau.

Ke ulu ikaika nei ka mākeke US 3,5-di-tert-butyl-4-hydroxybenzaldehyde, i alakaʻi ʻia e ka hoʻonui ʻana i nā hana noiʻi a me ka hoʻomohala ʻana (R&D) e nā hui lāʻau lapaʻau. ʻO ka piʻi ʻana o nā maʻi maʻi maʻi a me ka noi hou ʻana no nā lāʻau lapaʻau hou i hoʻoikaika hou i ka noi no nā intermediates kiʻekiʻe. Eia kekahi, ʻo ka ʻoihana lāʻau lapaʻau makua a me ke kaiapuni hoʻoponopono maikaʻi i ʻAmelika Hui Pū ʻIa i kōkua i ka ulu nui ʻana o kēia pūhui.

Ma ʻEulopa, ua like ke kūlana, me nā ʻāina e like me Kelemania, Farani a me UK e alakaʻi ana i ka hoʻohana ʻana i ka 3,5-di-tert-butyl-4-hydroxybenzaldehyde. Hōʻike ʻia ka mākeke lāʻau lapaʻau ʻEulopa e nā kūlana koʻikoʻi koʻikoʻi a me nā hoʻoponopono, e koi ana i nā mea hana e ʻimi i nā kumu hilinaʻi o nā intermediates pharmaceutical. Hoʻopili ka hui i nā alakaʻi alakaʻi ʻo European Medicines Agency (EMA), e lilo ia i koho maikaʻi no nā ʻoihana e ʻimi nei e hoʻomaikaʻi i kā lākou waihona huahana.

Eia kekahi, ʻo ka ulu ʻana o ka nānā ʻana i ka hoʻomau a me nā hana kemika ʻōmaʻomaʻo ma ʻAmelika Hui Pū ʻIa a me ʻEulopa ua alakaʻi i kahi hoʻololi i ka sourcing waena. Hoʻokumu mua nā mea hana i nā mea hoʻolako e pili ana i nā hoʻomaʻamaʻa kūlohelohe, e hoʻonui hou i ka noi no 3,5-di-tert-butyl-4-hydroxybenzaldehyde. Hiki i nā ʻoihana ke hōʻike i ka hoʻokō ʻana i nā ʻano hana hoʻomau e loaʻa ai ka lanakila hoʻokūkū ma ka mākeke.

Ke ulu nei ke kaulahao lako no 3,5-di-tert-butyl-4-hydroxybenzaldehyde, a ke ʻimi nei nā mea hana i nā hoʻolālā hoʻolālā hou e hōʻoia i ka lako paʻa o kēia kī waena. ʻO ka hui pū ʻana ma waena o nā mea hana kemika a me nā ʻoihana lāʻau lapaʻau e lilo i mea maʻamau i ka ʻimi ʻana o lāua ʻelua e hoʻomaikaʻi i nā kaʻina hana a hoʻemi i nā kumukūʻai. Ke manaʻo ʻia nei e hoʻomau ʻia kēia ʻano no ka mea e ikaika mau ana ka koi no nā mea waena kiʻekiʻe.

I ka hopena, ʻo ka mākeke no 3,5-di-tert-butyl-4-hydroxybenzaldehyde ma ke ʻano he lāʻau lapaʻau e manaʻo ʻia e ulu nui i ka United States a me ʻEulopa. ʻO ka versatility o ka pūhui, ka hoʻokō ʻana i nā kūlana hoʻoponopono a me ka alignment me nā pahuhopu hoʻomohala hoʻomau e lilo ia i waiwai waiwai no ka ʻoihana lāʻau. Ke hoʻomau nei ka piʻi ʻana o ka noi no nā lāʻau lapaʻau hou, ʻo ke koʻikoʻi o nā kikowaena hilinaʻi a kiʻekiʻe hoʻi e like me 3,5-di-tert-butyl-4-hydroxybenzaldehyde e hoʻonui wale ʻia, e hana ana i ka ʻāina e hiki mai ana o ka hana lāʻau lapaʻau ma kēia mau wahi.