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Nicorandil（CAS# 65141-46-0) Ki‘i Mana‘o
  • Nicorandil（CAS# 65141-46-0) 1

Nicorandil（CAS# 65141-46-0)

Waiwai Kemika:

ʻĀpana Molekala C8H9N3O4
Molar Mass 211.17
ʻO ka mānoanoa 1.4271 (manaʻo koʻikoʻi)
Lae hehee 92°C
Lae Boling 350.85°C (manaʻo koʻikoʻi)
Lae Flash 230°C
Ka hoʻoheheʻe DMSO: >10 mg/mL. Hiki ke hoʻoheheʻe ʻia i loko o ka methanol, ethanol, acetone a i ʻole glacial acetic acid, hiki ke hoʻoheheʻe ʻia i loko o ka chloroform a i ʻole ka wai, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka etera a i ʻole benzene.
Puʻupuʻu mahu 1.58E-08mmHg ma 25°C
Ka nana aku Keʻokeʻo a keʻokeʻo-like crystalline pauda
kala kala keʻokeʻo keʻokeʻo
ʻO Merck 14,6521
Kūlana Waihona 2-8°C
Hōʻike Hōʻike 1.7400 (manaʻo)
MDL MFCD00186520
Na Waiwai Kino a Kimia ʻO ka pauka kristal keʻokeʻo, ʻaʻala ʻole a ʻala iki paha, ʻawaʻawa. Hiki ke hoʻoheheʻe ʻia i loko o ka methanol, ethanol, acetone a i ʻole acetic acid, hiki ke hoʻoheheʻe ʻia i loko o ka chloroform a i ʻole ka wai, ʻaʻole e hoʻoheheʻe ʻia kekahi i ka etera a i ʻole benzene. Ka helu hehee 88.5-93.5 °c. ʻona ʻawaʻawa LD50 ʻiole (mg/kg):1200-1300 waha, 800-1000 intravenous.
Hoʻohana No ka pale ʻana i ka maʻi naʻau coronary, angina pectoris
Haʻawina in vitro Ua hoʻonui ʻo Nicorandil (100 mM) i ka oxidation flavoprotein, akā ʻaʻole i hoʻopilikia i ka manawa membrane, hoʻihoʻi i nā ala mitoK (ATP) a me surfaceK (ATP) ma nā ʻano kiʻekiʻe ma mua o 10-fold. Hoʻemi ʻo Nicorandil i ka make cell i loko o kahi kumu hoʻohālike ischemic granulation, kahi hopena cardioprotective i pale ʻia e ka mitoK(ATP) channel blocker 5-hydroxydecanoic acid akā ʻaʻole na ka surfaceK(ATP). Ka hopena o ka mea hoʻopaʻa ala HMR1098. ʻO Nicorandil (100 mM) ke kāohi i ka nalowale o TUNEL positivity, cytochrome C translocation, caspase-3 activation, a me mitochondrial membrane potential (Delta (Psi) (m)). ʻO ka nānā ʻana o nā pūnaewele i hoʻopaʻa ʻia me ka fluorescence Delta(Psi)(m)-indicator, tetramethylrhodamine ethyl ester (TMRE) e ka fluorescence activated cell sorter i hōʻike ʻia, ua pale ʻo nicorandil i ka depolarization Delta(Psi)(m) ma ke ʻano hilinaʻi (EC(50). ) ma kahi o 40 mM, saturation 100 mM). I loko o nā pūnaewele ʻelua i hoʻololi ʻia, ua hoʻāla ʻo Nicorandil i kahi kahawai 80 pS K hoʻoponopono nāwaliwali i loko, glibenclamide-sensitive. Ma nā pūnaewele HEK293T, ʻoi aku ka maikaʻi o Nicorandil e hoʻāla i ke kahawai K(ATP) i loaʻa iā SUR2B. ʻO Nicorandil (100 mM) i kāohi nui i ka helu o nā pūnaewele i loko o ka TUNEL-positive nuclei a hoʻonui i ka 20 mM h2o2-induced caspase-3 hana. Kākoʻo ʻo Nicorandil i ka nalo ʻana o DeltaPsim i hoʻokomo ʻia e H2O2.
In vivo haʻawina ʻO Nicorandil (2.5 mg / kg i kēlā me kēia lā, po) i hui pū me Amlodipine (5.0 mg / kg i kēlā me kēia lā, po) ʻekolu lā o ka hana i pale nui i nā loli a hoʻihoʻi i ka hana enzyme i nā pae kokoke i nā ʻiole maʻamau.

Huahana Huahana

Huahana Huahana

Nā hōʻailona pōʻino Xn – Poino
Nā Code Risk R22 – Poino ke aleia
R41 – Ka pilikia o ka poino nui i na maka
Ka wehewehe palekana S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino.
S39 - Hoʻohana i ka pale maka / maka.
WGK Kelemānia 3
RTECS US4667600
HS Code 29333990
Kaʻawaʻawa LD50 i nā ʻiole (mg/kg): 1200-1300 waha; 800-1000 iv (Nagano)

 

Hoʻolauna

ʻO Nicolandil, i kapa ʻia ʻo nicorandil amine, he mea hoʻohuihui. ʻO kēia ka hoʻolauna ʻana i nā waiwai, hoʻohana, hoʻomākaukau a me ka ʻike palekana o nicorandil:

 

ʻAno maikaʻi:

- ʻO Nicorandil kahi paʻa kristal kala ʻole i hiki ke hoʻoheheʻe ʻia i ka wai a me nā mea hoʻoheheʻe organik.

- He pūhui alkaline hiki ke hana me nā ʻakika e hana i nā pūhui paʻakai.

- Paʻa ʻo Nicorandil i ka lewa, akā hiki ke hoʻoheheʻe ʻia ke ʻike ʻia i nā wela kiʻekiʻe.

 

E hoʻohana:

- Hiki ke hoʻohana ʻia ʻo Nicolandil i ka synthesis o nā catalysts synthesis organik, photosensitizers, etc.

 

Hanana:

- Hoʻomākaukau ʻia ʻo Nicolandil e ka hopena o ka dimethylamine a me 2-carbonyl pūhui.

- Hoʻokō ʻia ka hopena ma lalo o nā kūlana alkaline a lawe ʻia ka hopena wela i kahi solvent kūpono.

 

ʻIke palekana:

- He palekana ʻo Nicorandil no nā kānaka ma lalo o nā kūlana maʻamau.

- Eia naʻe, pono e mālama ʻia e pale aku i ka pili pono ʻana me nā maka, ka ʻili, a me ka ʻōnaehana hanu.

- E hoʻohana i nā lako pale pilikino (PPE) kūpono e like me nā aniani palekana, nā mīkina lima a me nā mea hanu.

- I ka hoʻohana ʻana a mālama ʻana paha i ka nicorandil, pono e mālama i ka pale ʻana i ke ahi a me nā kūlana wela kiʻekiʻe.

 

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