Papaverine Hydrochloride(CAS#61-25-6)
Nā Code Risk | R22 – Poino ke aleia R34 - Ke kumu o ke kuni R11 – Hiki ke ahi |
Ka wehewehe palekana | S22 – Mai hanu i ka lepo. S45 – Inā loaʻa ka pōʻino a i ʻole ka maikaʻi ʻole, e ʻimi koke i ka ʻōlelo aʻo kino (e hōʻike i ka lepili inā hiki.) S36/37/39 – E hoʻohana i nā lole pale kūpono, nā mīkina lima a me ka pale maka/maka. S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. S16 – E hoʻokaʻawale i nā kumu hoʻā. |
UN ID | UN 1544 6.1/PG 3 |
WGK Kelemānia | 1 |
RTECS | NW8575000 |
NUI FLUKA BRAND F | 8 |
TSCA | ʻAe |
HS Code | 29391900 |
Papa Hazard | 6.1 |
Hui Pūʻulu | III |
Kaʻawaʻawa | LD50 i nāʻiole, nāʻiole (mg/kg): 27.5, 20 iv; 150, 370 sc (Levis) |
Papaverine Hydrochloride(CAS#61-25-6)
ʻO Papaverine hydrochloride, ka helu CAS 61-25-6, he mea koʻikoʻi i loko o ka lāʻau lapaʻau.
Mai ka manaʻo o nā waiwai kemika, ʻo ia ke ʻano hydrochloride o papaverine, a ʻo ke ʻano kemika e hoʻoholo i kāna mau waiwai. ʻO ka hoʻonohonoho ʻana o nā ʻātoma a me ka hoʻonohonoho ʻana o nā mea paʻa kemika i loko o ka molecular structure e hāʻawi iā ia i ke kūpaʻa kūʻokoʻa a me ka reactivity. He keʻokeʻo maʻamau ka hiʻohiʻona a hiki i ka pauka crystalline melemele māmā, kahi kūpono i ka hana, mālama a me ka lawe ʻana i nā lāʻau lapaʻau. I ka ʻōlelo o ka solubility, he haʻahaʻa haʻahaʻa kona i ka wai, a ʻo nā ʻano ʻokoʻa like ʻole o ka acid-base a me nā kūlana mahana e hoʻopilikia i kona mau hiʻohiʻona solubility, ʻo ia ke koʻikoʻi nui no ka hoʻokumu ʻana i nā lāʻau lapaʻau, ka hoʻomohala ʻana i nā ʻano dosage, a pehea e hōʻoia ai i ka ʻaʻahu. ka hoʻopuehu ʻana i nā lāʻau i ka wā e hana ai i nā injections a me ka hoʻomākaukau waha.
I ka ʻōlelo o ka pharmacological efficacy, ʻo Papaverine Hydrochloride ka papa o nā mea hoʻomaha hoʻomaha. Hoʻohana nui ia i ka ʻiʻo maʻemaʻe o nā kīʻaha koko, ka ʻōpū o ka ʻōpū, ka ʻāpana biliary a me nā ʻāpana ʻē aʻe, a hoʻoikaika i ka hoʻomaha ʻana o ka ʻiʻo ma o ka hoʻopili ʻana i nā mīkini e like me ka intracellular calcium ion transport. ʻO ka maʻi maʻi, hoʻohana pinepine ʻia e mālama i ka ischemia i hoʻokumu ʻia e ka vasospasm, e like me ka maʻi ʻeha a me ka dizziness i hana ʻia e ka cerebral vasospasm, hiki ke hoʻomaikaʻi i ke kahe koko kūloko; He hopena hoʻomaha koʻikoʻi ia i ka ʻeha ʻōpū a me ka colic biliary i hoʻokumu ʻia e ka spasm gastrointestinal, e hōʻemi ana i ka ʻeha o nā maʻi.
Eia naʻe, e like me ka nui o nā lāʻau lapaʻau, he mea nui e hahai i nā ʻōlelo aʻoaʻo a kāu kauka i ka wā e hoʻohana ai. Ma muli o nā hana kino like ʻole a me nā maʻi i lalo o kēlā me kēia maʻi, pono nā kauka e ana i ka makahiki o ka mea maʻi, ka ate a me ka hana ʻana o ka maʻi, nā lāʻau ʻē aʻe i lawe ʻia a me nā kumu ʻē aʻe, a hoʻoholo pololei i ke ʻano, ke ala o ka lawelawe ʻana a me ke ʻano o ka lāʻau lapaʻau, no laila e hōʻoia i ka palekana a me ka maikaʻi o ka lāʻau, a kōkua i ka mea maʻi e ola hou. Me ka holomua o ka noiʻi ʻepekema, ka noiʻi ʻana a me ka hoʻomohala ʻana i nā ʻano dosage hou a me ka hoʻonui ʻia ʻana o nā lāʻau lapaʻau a puni ia.