(S)-(-)-1 2-Diaminopropane dihydrochloride（CAS# 19777-66-3)
Pilikia a palekana
| Nā Code Risk | R36/37/38 – Hoʻonanea i ka maka, ka ʻōpū hanu a me ka ʻili. R23/24/25 – He mea make ma ka inhalation, pili me ka ili a ina e ale. |
| Ka wehewehe palekana | S26 – Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino. S36 – E komo i nā lole pale kūpono. S45 – Inā loaʻa ka pōʻino a i ʻole ka maikaʻi ʻole, e ʻimi koke i ka ʻōlelo aʻo kino (e hōʻike i ka lepili inā hiki.) S36/37/39 – E hoʻohana i nā lole pale kūpono, nā mīkina lima a me ka pale maka/maka. |
| WGK Kelemānia | 3 |
| NUI FLUKA BRAND F | 10-21 |
| HS Code | 29212900 |
(S)-(-)-1 2-Diaminopropane dihydrochloride（CAS# 19777-66-3) ʻIkepili
| Nānā nui | (S)-(-)-diaminopropane dihydrochloride hiki ke hoʻohana ma ke ʻano he pharmaceutical synthesis intermediate, e like me ka hoʻomākaukau ʻana o Dexrazoxane, ʻo ia ka dextrorotatory enantiomer o ka lāʻau antitumor razoxane. No nā lāʻau lapaʻau pale puʻuwai, ke kauka no ka pale ʻana i nā lāʻau anthracycline anticancer i hoʻokumu ʻia e ka maʻi maʻi puʻuwai a me ka maʻi leukemia i nā keiki ma muli o ka chemotherapy i hoʻokumu ʻia e ka hōʻeha puʻuwai, pinepine ma ke ʻano he adjuvant i ka mālama ʻana i ka maʻi kanesa. |
| Hoʻohana | (S)-(-)-diaminopropane ʻO Dihydrochloride kahi mea waena, hiki ke hoʻomākaukau ʻia ma ka hana ʻana i ka D-(-)-tartaric acid a me propylenediamine. Ua hoʻohana ʻia ka diamine i ka synthesis o nā pūhui imidazoline chiral |
| hoomakaukau ana | ka hoʻomākaukau ʻana o (S)-(-)-diaminopropane dihydrochloride: hoʻohui i ka 30.0gD-(-)-tartaric acid a me 8.0 ml wai a me g (±)-1, 2-propanediamine i loko o ka pahu hopena, hoʻoulu e hoʻoheheʻe, hoʻohui, hoʻohui. Dropwise, ua hoʻokiʻekiʻe ʻia ka mahana i reflux no 2 mau hola me ka hoʻoulu ʻana. Ua ho'ōkiʻia ka hoʻouluʻana, a ua hoʻonuiʻia ka mahana i 80 ° C. No 1 hola. A laila, ua hoʻohaʻahaʻa mālie a hoʻohaʻahaʻa ʻia ka mahana i ka lumi wela, kānana ʻia, a hoʻomaloʻo ʻia ka maloʻo no ka loaʻa ʻana o 16.1g o (S) -1, 2-propanediamine ditartrate. E hoʻohui i 16.1g o (S)-1, 2-propanediamine ditartrate a me ka wai i ka pahu hopena, e hoʻoheheʻe me ka hoʻomehana, a laila e hoʻohui i kahi hopena o 7.43g o ka potassium chloride a me 20ml wai, ua hoʻoulu ʻia ka hui ʻana ma 70 °c. no 2 hola. Ma hope o ka hoʻoluʻu ʻana, ua ʻae ʻia ka friji e kū no ka crystallization. Ua kānana ʻia ka kānana me ka momi a hoʻomaloʻo i ka maloʻo ma lalo o ke kaomi hoʻemi ʻia e hāʻawi i 84% G o ka paʻa melemele (3), hua 4.02, [α]20D =-°(C = 1%,H2O). |
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