tert-butyl 2 4-dioxopiperidine-1-carboxylate（CAS# 845267-78-9)

ʻĀpana Molekala	C10H15NO4
Molar Mass	213.23
ʻO ka mānoanoa	1.199
Lae Boling	373.8±35.0 °C(Wānana ʻia)
Lae Flash	179.9°C
Puʻupuʻu mahu	8.72E-06mmHg ma 25°C
pKa	10.67±0.20(Wānana ʻia)
Kūlana Waihona	E mālama ma kahi pouli, Hoʻopaʻa ʻia i kahi maloʻo, Ke ana wela o ka lumi
Hōʻike Hōʻike	1.493
MDL	MFCD10566071

Huahana Huahana

Nā Code Risk	20/21/22 – He pōʻino ma ka inhalation, pili me ka ʻili a inā ale ʻia.
Ka wehewehe palekana	S23 – Mai hanu i ka mahu. S24/25 – Hōʻalo i ka pili ʻana me ka ʻili a me nā maka.
WGK Kelemānia	3
HS Code	29337900

Hoʻohana	2, 4-dipiperidon-1-formate tert-butyl formate ʻo ia ka synthesis o phenoxymethyl-dihydrothiazolopyridone derivatives Reactants i loko o ka huahana, ma ke ʻano he modulator hoʻonohonoho maikaʻi koho (PAM) o ka mea hoʻokipa metabolized glutamate 5(mGlu5).
palapala noi	2, 4-dioperidone-1-tert-butyl formate ua hoʻohana nui ʻia ma ke ʻano he waena waena a me ka lāʻau lapaʻau, a hiki ke hoʻohana ʻia i ka noiʻi noiʻi a me ke kaʻina hana hoʻomohala a me ke kaʻina hana synthesis.
hoomakaukau ana	'anuʻu a: e hoʻohui i ka EDCI (191.7g) i ka DMF (400mL) solution o 3-(tert-butoxycarbonylamino) propionic acid (189.2g,1.0mol), meldamic acid (144.1g,1.0mol) a me DMAP (135.0g,1.1mol). ) hoʻoluʻu ʻia e ka ʻauʻau hau, 1.0mol). Ua hoʻoulu ʻia nā reactants i ka pō i ka mahana wela. Ua kinai ʻia ka hopena me 200mL H2O. Hoʻohui ʻia ka hui ʻana i ka hāʻule i ka H2O(2.0L) ma lalo o ka hoʻoulu ʻana. Ua kānana ʻia ka paʻa paʻa a holoi pono ʻia me ka wai a hiki i ka pH 7 e loaʻa ai ka huahana (283g,90% yield). KaʻAnuʻu B: He hopena o 3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl) -3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) i toluene (1500mL) ua wela ma 100°C no 4 mau hola. Hoʻomaʻalili ʻia nā reactants i ka lumi wela a hoʻopaʻa ʻia ma lalo o ke kaomi hoʻemi ʻia e loaʻa ai kahi huahana pala. Ua hoʻomaʻemaʻe ʻia ka huahana (56g,83% yield) e ka MTBE-wili.