Z-DL-ALA-OH（CAS# 4132-86-9)

Hoʻolauna

ʻO N-Carbobenzyloxy-DL-alanine he mea hoʻohuihui olaola, i hoʻopau pinepine ʻia ʻo Cbz-DL-Ala. ʻO kēia ka wehewehe ʻana o kona ʻano, hoʻohana, hana a me ka ʻike palekana:

ʻAno:

ʻO ka N-Carbobenzyloxy-DL-alanine he paʻa keʻokeʻo keʻokeʻo me ke ʻano molekala o C12H13NO4 a me ka nui molekala pili o 235.24. Loaʻa iā ia ʻelua mau kikowaena chiral a no laila e hōʻike ana i nā isomers optical. Hiki ke hoʻoheheʻe ʻia i loko o nā mea hoʻoheheʻe kūlohelohe, e like me ka waiʻona a me ka dimethylformamide. He mea paʻa a paʻakikī ke hoʻoheheʻe ʻia.

E hoʻohana:

ʻO N-Carbobenzyloxy-DL-alanine ka mea hoʻohana maʻamau i hoʻohana ʻia i ka derivative amino acid pale. Hiki ke hoʻohana ʻia i ka synthesis o nā peptides a me nā protein i hiki ke hoʻopili ʻia kāna mau hui carboxyl a me nā amine e nā hopena condensation ma waena o nā waikawa amino e hana i nā kaulahao peptide. Hiki ke hoʻoneʻe ʻia ka pūʻulu pale N-benzyloxycarbonyl e nā kūlana kūpono ma hope o ka pau ʻana o ka hopena e hoʻihoʻi i ke ʻano amino acid kumu.

Kaʻina hoʻomākaukau:

Hana ʻia ka hoʻomākaukau ʻana o N-Carbobenzyloxy-DL-alanine me ka hoʻohana ʻana i ka N-benzyloxycarbonyl-alanine a me kahi nui kūpono o DCC (diisopropylcarbamate) i loko o kahi solvent kūpono. Dehydrates ka hopena e hana i kahi ʻano amide, a laila hoʻomaʻemaʻe ʻia e ka crystallization e hāʻawi i ka huahana i makemake ʻia.

ʻIke palekana:

Mālama ʻia ka N-Carbobenzyloxy-DL-alanine ke hoʻohana ʻia ma lalo o nā kūlana hana kūpono. Eia nō naʻe, no ka mea he kemika ia, pono e hahai ʻia nā alakaʻi no nā hana hoʻokolohua palekana. Hiki ke hoʻonāukiuki i nā maka a me ka ʻili, no laila e hoʻokomo i nā lako pale pilikino kūpono e like me nā mīkina lima a me nā maka aniani i ka wā o ka hana. Eia kekahi, pono e mālama ʻia ma kahi maloʻo a maikaʻi, kahi mamao mai ke ahi a me nā mea hiki ke ahi. No ka ʻike kikoʻī hou aku e pili ana i kā lākou mālama pono ʻana a me ka mālama ʻana, e nānā i ka pepa ʻikepili palekana pili (SDS) o ke kemika a i ʻole e nīnau i kahi loea.